التفاصيل البيبلوغرافية
| العنوان: |
The Influence of Exposure to Maternal Diabetes In Utero on the Rate Of Decline in Beta-Cell Function Among Youth with Diabetes ; J Pediatr Endocrinol Metab |
| المساهمون: |
Crume, T.L., Andrews, J.S., D’Agostino, R., Pettitt, D.J., Mayer-Davis, E.J., Law, J.R., Dolan, L., Lawrence, J.M., Saydah, S., Greenbaum, C., Rodriguez, B.L., Dabelea, D., The SEARCH for Diabetes in Youth Study Group |
| المصدر: |
J Pediatr Endocrinol Metab. 26(0):721-727. |
| المجموعة: |
CDC Stacks (Centers for Disease Control and Prevention) |
| مصطلحات موضوعية: |
Article, Gestational diabetes, fetal overnutrition, fetal exposure to diabetes, childhood type 2 diabetes, type 1 diabetes, diabetes during pregnancy, beta-cell function, fasting C-peptide, Adolescent, C-Peptide, Child, Diabetes Mellitus, Type 1, Type 2, Diabetes, Gestational, Female, Humans, Insulin-Secreting Cells, Male, Pregnancy |
| الوصف: |
We explored the influence of exposure to maternal diabetes in utero on β cell decline measured by fasting C-peptide (FCP) among 1079 youth <20 years with diabetes, including 941 with type 1 and 138 with type 2 diabetes. Youths exposed to maternal diabetes had FCP levels that were 17% lower among youth with type 2 diabetes [95% confidence interval (CI): -34%, +6%] and 15% higher among youth with type 1 diabetes (95%CI: -14%, +55%) than their unexposed counterparts, although differences were not statistically significant (p=0.13 and p=0.35, respectively). Exposure to maternal diabetes was not associated with FCP decline in youth with type 2 (p=0.16) or type 1 diabetes (p=0.90); nor was the effect of in utero exposure on FCP modified by diabetes type. Findings suggest that exposure to maternal diabetes in utero may not be an important determinant of short-term β-cell function decline in youth with type 1 or type 2 diabetes. ; P30 DK057516/DK/NIDDK NIH HHS/United States ; M01RR00037/RR/NCRR NIH HHS/United States ; U01 DP000247/DP/NCCDPHP CDC HHS/United States ; U18 DP002710/DP/NCCDPHP CDC HHS/United States ; U01 DP000245/DP/NCCDPHP CDC HHS/United States ; R01 DK059184/DK/NIDDK NIH HHS/United States ; M01 RR000069/RR/NCRR NIH HHS/United States ; U18 DP002714/DP/NCCDPHP CDC HHS/United States ; U01 DP000248/DP/NCCDPHP CDC HHS/United States ; M01 RR000037/RR/NCRR NIH HHS/United States ; U01 DP000244/DP/NCCDPHP CDC HHS/United States ; P30 DK57516/DK/NIDDK NIH HHS/United States ; 1UL1RR026314-01/RR/NCRR NIH HHS/United States ; UL1 RR025014/RR/NCRR NIH HHS/United States ; UL1 RR029882/RR/NCRR NIH HHS/United States ; M01 RR00069/RR/NCRR NIH HHS/United States ; U18 DP002709/DP/NCCDPHP CDC HHS/United States ; UL1 TR000077/TR/NCATS NIH HHS/United States ; U01 DP000250/DP/NCCDPHP CDC HHS/United States ; U01 DP000246/DP/NCCDPHP CDC HHS/United States ; U01 DP000254/DP/NCCDPHP CDC HHS/United States ; UL1 RR026314/RR/NCRR NIH HHS/United States ; U18 DP002708/DP/NCCDPHP CDC HHS/United States ; UL1RR029882/RR/NCRR NIH ... |
| نوع الوثيقة: |
other/unknown material |
| اللغة: |
unknown |
| العلاقة: |
cdc:41971; http://stacks.cdc.gov/view/cdc/41971Test/ |
| الإتاحة: |
http://stacks.cdc.gov/view/cdc/41971Test/ |
| رقم الانضمام: |
edsbas.93C3B60D |
| قاعدة البيانات: |
BASE |
