دورية أكاديمية
Hypoxia modulates the antioxidant effect of hydroxytyrosol in MCF-7 breast cancer cells
| العنوان: | Hypoxia modulates the antioxidant effect of hydroxytyrosol in MCF-7 breast cancer cells |
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| المؤلفون: | Calahorra, Jesús, Martínez-Lara, Esther, Dios, Cristina de, Siles, Eva |
| المساهمون: | Siles, Eva |
| بيانات النشر: | Public Library of Science |
| سنة النشر: | 2018 |
| المجموعة: | Digital.CSIC (Consejo Superior de Investigaciones Científicas / Spanish National Research Council) |
| الوصف: | Although cancer is multifactorial, a strong correlation between this pathology and increased oxidative stress has long been stablished. Hypoxia, inherent to solid tumors, increases reactive oxygen species and should be taken into account when analyzing the response of tumor cells to antioxidants. The Mediterranean diet has been related to a lower incidence of cancer, and particularly of breast cancer. Given that hydroxytyrosol (HT) is largely responsible for the antioxidant properties of olive oil, we have performed a comprehensive and comparative study of its effect on the oxidative stress response of the human breast cancer cell line MCF-7 in hypoxia and normoxia. Our results demonstrate that the antioxidant action of HT is particularly effective in a hypoxic environment. Moreover, we have observed that this polyphenol modulates the transcription and translation of members of the PGC-1α/ERRα and PGC-1α/Nrf2 pathways. However, while the transcriptional effects of HT are similar in normoxic and hypoxic conditions, its translational action is less prominent and partially attenuated in hypoxia, and therefore cannot completely explain the antioxidant effect of HT. Consequently, our results underscore that the hypoxic environment of tumor cells should be considered when analyzing the effect of bioactive compounds. Besides, this study also points to the importance of assessing the regulatory role of HT at both mRNA and protein level to get a complete picture of its effects. ; Peer reviewed |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1932-6203 |
| العلاقة: | Publisher's version; https://doi.org/10.1371/journal.pone.0203892Test; Sí; PLoS ONE 13(9): e0203892 (2018); http://hdl.handle.net/10261/177175Test |
| DOI: | 10.1371/journal.pone.0203892 |
| الإتاحة: | https://doi.org/10.1371/journal.pone.0203892Test http://hdl.handle.net/10261/177175Test |
| حقوق: | open |
| رقم الانضمام: | edsbas.93A83AD |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 19326203 |
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| DOI: | 10.1371/journal.pone.0203892 |