دورية أكاديمية
The hepatokine FGF21 increases the human spermatozoa motility
| العنوان: | The hepatokine FGF21 increases the human spermatozoa motility |
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| المؤلفون: | Bourdon, Guillaume, Estienne, Anthony, Chevaleyre, Claire, Ramé, Christelle, Guerif, Fabrice, Brun, Jean Sebastien, Vasseur, Claudine, Fromont, Gaëlle, Plotton, Ingrid, Dufour-Rainfray, Diane, Caldas-Silveira, Erika, Dupont, Joëlle, Froment, Pascal, Ducluzeau, Pierre-Henri |
| المساهمون: | Physiologie de la reproduction et des comportements Nouzilly (PRC), Institut Français du Cheval et de l'Equitation Saumur (IFCE)-Université de Tours (UT)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), Pôle Santé Léonard de Vinci Chambray-lès-Tours (PSLV / Clinique), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon |
| المصدر: | ISSN: 1664-2392 ; Frontiers in Endocrinology ; https://hal.inrae.fr/hal-03742076Test ; Frontiers in Endocrinology, 2022, 13, pp.1-13. ⟨10.3389/fendo.2022.775650⟩. |
| بيانات النشر: | HAL CCSD Frontiers |
| سنة النشر: | 2022 |
| المجموعة: | Université François-Rabelais de Tours: HAL |
| مصطلحات موضوعية: | human, spermatozoa, FGF21 (fibroblast growth factor 21), sperm moTility, metabolism diseases, fertility, [SDV.SA]Life Sciences [q-bio]/Agricultural sciences, [SDV.BDLR]Life Sciences [q-bio]/Reproductive Biology |
| الوصف: | International audience ; Lifestyle, environment and excess body weight are not only associated with an increased risk of metabolic disorders, such as type 2 diabetes, but also to other pathological processes, such as infertility. A hormone produced mainly by the liver called fibroblast growth factor 21 (FGF21) is closely linked to the energy status and is increased in patients suffering from obesity or insulin resistance. Recently, FGF21 has been shown to be associated with female fertility disorders, but no or few data about the role of FGF21 on human male fertility has been described. In the present study, FGF21 was measured in the seminal fluid at a lower level in comparison to the blood level. Thus, in the present in vitro study, we aimed to decipher the FGF21 system in human semen. To evaluate the putative role of FGF21 on spermatozoa function, we incubated human spermatozoa with increasing concentrations of recombinant human FGF21. The FGF21 in seminal fluid is potentially produced by male reproductive tract tissues. In spermatozoa, the FGF21 signal was transduced by the two main receptors FGFR1-c and FGFR3 and the cofactor beta-klotho, which are colocalized in the middle piece of spermatozoa and stimulated the PI3K/Akt and MAPK pathways. Finally, in vitro treatment by FGF21 significantly increased sperm motility and ATP levels. Concomitantly, exposure to FGF21 improved the oxidative stress, as a lower ROS level was observed. Overall, these results seem to indicate that the metabolic factor, FGF21, positively modifies the activity and quality of the parameters of human spermatozoa. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | hal-03742076; https://hal.inrae.fr/hal-03742076Test; https://hal.inrae.fr/hal-03742076/documentTest; https://hal.inrae.fr/hal-03742076/file/BourdonG_FrontiersEndocrin_2022.pdfTest; WOS: 000766902400001 |
| DOI: | 10.3389/fendo.2022.775650 |
| الإتاحة: | https://doi.org/10.3389/fendo.2022.775650Test https://hal.inrae.fr/hal-03742076Test https://hal.inrae.fr/hal-03742076/documentTest https://hal.inrae.fr/hal-03742076/file/BourdonG_FrontiersEndocrin_2022.pdfTest |
| حقوق: | http://creativecommons.org/licenses/byTest/ ; info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.938C8E27 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3389/fendo.2022.775650 |
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