دورية أكاديمية
Analysis of the characteristics of agitated behavior and its influencing factors in patients with cognition disorders
| العنوان: | Analysis of the characteristics of agitated behavior and its influencing factors in patients with cognition disorders |
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| المؤلفون: | Yu⁃chen QIAO, Hong CHANG, Jia⁃mei WANG, Xuan YANG, Na WEI, Ai⁃cong DING |
| المصدر: | Chinese Journal of Contemporary Neurology and Neurosurgery, Vol 23, Iss 4, Pp 310-325 (2023) |
| بيانات النشر: | Tianjin Huanhu Hospital |
| سنة النشر: | 2023 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | lewy body disease, orexins, risk factors, logistic models, Neurology. Diseases of the nervous system, RC346-429 |
| الوصف: | Objective To analyze the correlations between plasma orexin⁃A and clinical manifestations of dementia with Lewy bodies (DLB). Methods A total of 51 patients with DLB from Beijing Tiantan hospital, Capital Medical University, and 46 sex, age and education matched controls were conducted from January 2019 to December 2021. Overall cognitive function was assessed by Mini⁃Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA), dementia severity was assessed by Clinical Dementia Rating Scale (CDR), activities of daily living was assessed by Activities of Daily Living Scale (ADL), depression severity was assessed by Hamilton Depression Rating Scale 17 (HAMD⁃17), neuropsychiatric symptoms was assessed by Neuropsychiatric Inventory (NPI), and plasma orexin⁃A level was measured. The univariate and multivariate Logistic regression analyses were used to screen influencing factors for DLB. Pearson and partial correlation analyses were used to explore the correlation between plasma orexin⁃A and core clinical features of DLB. Multivariate linear stepwise regression analysis was used to analyze the linear correlation between plasma orexin⁃A level and neuropsychological tests. Results The scores of MMSE (Z=⁃ 8.387, P=0.000) and MoCA (Z=⁃8.479, P=0.000) in DLB group were significantly lower than those in control group, while the scores of CDR (Z=⁃9.072, P = 0.000), ADL(Z=⁃8.692, P=0.000), HAMD⁃17 (Z=⁃7.568, P=0.000), NPI (Z=⁃8.270, P=0.000) and plasma orexin⁃A level (Z=⁃2.688, P=0.007) were significantly higher than those in control group. Plasma orexin⁃A level in DLB patients with fluctuating cognition (Z=⁃2.172, P=0.030) and with Parkinsonism (Z=⁃1.981, P=0.048) were lower than those without these symptoms, respectively. Logistic regression analysis showed drinking history was a potentially independent protective factor for DLB (OR=0.278, 95%CI:0.095-0.808; P=0.019), while increased plasma orexin⁃A level was an independent risk factor for DLB (OR=6.878, 95%CI:1.241-38.137; P=0.027). Correlation analysis ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English Chinese |
| تدمد: | 1672-6731 |
| العلاقة: | http://www.cjcnn.org/index.php/cjcnn/article/view/2663Test; https://doaj.org/toc/1672-6731Test; https://doaj.org/article/2d0f564ac1d3426fb4e8053d6dc8295aTest |
| DOI: | 10.3969/j.issn.1672⁃6731.2023.04.007 |
| الإتاحة: | https://doi.org/10.3969/j.issn.1672Test⁃6731.2023.04.007 https://doaj.org/article/2d0f564ac1d3426fb4e8053d6dc8295aTest |
| رقم الانضمام: | edsbas.937DEAB8 |
| قاعدة البيانات: | BASE |
| تدمد: | 16726731 |
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| DOI: | 10.3969/j.issn.1672⁃6731.2023.04.007 |