دورية أكاديمية
Prognostic relevance of magnesium alterations in patients with a myocardial infarction and left ventricular dysfunction: insights from the EPHESUS trial
| العنوان: | Prognostic relevance of magnesium alterations in patients with a myocardial infarction and left ventricular dysfunction: insights from the EPHESUS trial |
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| المؤلفون: | Martens, Pieter, Ferreira, João, Pedro, Vincent, John, Abreu, Paula, Busselen, Martijn, Mullens, Wilfried, Tang, Wh, Wilson, Böhm, Michael, Pitt, Bertram, Zannad, Faiez, Rossignol, Patrick |
| المساهمون: | Ziekenhuis Oost-Limburg (ZOL), Hasselt University (UHasselt), Cleveland Clinic, Défaillance Cardiovasculaire Aiguë et Chronique (DCAC), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Centre d'investigation clinique plurithématique Pierre Drouin Nancy (CIC-P), Centre d'investigation clinique Nancy (CIC), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL)-Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Cardiovascular and Renal Clinical Trialists Vandoeuvre-les-Nancy (INI-CRCT), Institut Lorrain du Coeur et des Vaisseaux Louis Mathieu Nancy, French-Clinical Research Infrastructure Network - F-CRIN Paris (Cardiovascular & Renal Clinical Trialists - CRCT ), Pfizer, Saarland University Saarbrücken, University of Michigan Ann Arbor, University of Michigan System, The EPHESUS trial was sponsored by Pfizer, ANR-15-RHUS-0004,FIGHT-HF,Combattre l'insuffisance cardiaque(2015) |
| المصدر: | ISSN: 2048-8726 ; EISSN: 2048-8734. |
| بيانات النشر: | HAL CCSD SAGE Publications |
| سنة النشر: | 2022 |
| المجموعة: | Université de Lorraine: HAL |
| مصطلحات موضوعية: | myocardial infarction, heart failure, systolic dysfunction, eplerenone, hypomagnesemia, hypermagnesemia, electrolytes. ClinicalTrials.gov identifier: NCT00232180, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system |
| الوصف: | International audience ; Abstract Aims Magnesium changes are common in myocardial infarction (MI) complicated with left ventricular systolic dysfunction (LVSD) and/or heart failure (HF). The relation between serum magnesium and clinical outcomes is insufficiently elucidated in this population. Methods and results The EPHESUS trial randomized 6632 patients to either eplerenone or placebo. Hypomagnesemia and hypermagnesemia were defined as a serum magnesium <0.66 and >1.10 mmol/L, respectively. Linear mixed models and time-dependent Cox regression analysis were used to determine the effect of eplerenone on magnesium changes and the prognostic importance of magnesium. The co-primary outcomes were all-cause mortality and a composite of cardiovascular (CV) mortality and CV hospitalization. A total of 5371 patients had a post-baseline magnesium measurement. At baseline, 231 (4.3%) patients had hypomagnesemia and 271 (5.0%) patients had hypermagnesemia. During a median follow-up of 16 months, 682 (13%) developed hypomagnesemia and 512 (9.5%) hypermagnesemia. Eplerenone treatment did not result in a different magnesium level during follow-up (P = 0.14). After covariate adjustment hypo- and hypermagnesemia were not associated with a higher risk of CV events. Magnesium levels did not modulate the effect of a high potassium (>5 mmol/L) or low potassium (<4 mmol/L) on the clinical outcome. Baseline magnesium levels did not influence the treatment effect of eplerenone (P-interaction > 0.1 for all primary and secondary endpoints). Conclusion In patients with MI complicated by LVSD or HF, magnesium alterations were not associated with clinical outcomes nor did they influence the effect of eplerenone. Serum magnesium did not modulate the effect of potassium changes on clinical outcome or the treatment effect of eplerenone. ClinicalTrials.gov identifier NCT00232180. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/35021200; hal-03529833; https://hal.univ-lorraine.fr/hal-03529833Test; https://hal.univ-lorraine.fr/hal-03529833/documentTest; https://hal.univ-lorraine.fr/hal-03529833/file/Magnesium%20and%20EPHESUS.pdfTest; PUBMED: 35021200 |
| DOI: | 10.1093/ehjacc/zuab111 |
| الإتاحة: | https://doi.org/10.1093/ehjacc/zuab111Test https://hal.univ-lorraine.fr/hal-03529833Test https://hal.univ-lorraine.fr/hal-03529833/documentTest https://hal.univ-lorraine.fr/hal-03529833/file/Magnesium%20and%20EPHESUS.pdfTest |
| حقوق: | info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.92E1A5F1 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/ehjacc/zuab111 |
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