دورية أكاديمية
MATRix–RICE therapy and autologous haematopoietic stem-cell transplantation in diffuse large B-cell lymphoma with secondary CNS involvement (MARIETTA): an international, single-arm, phase 2 trial
| العنوان: | MATRix–RICE therapy and autologous haematopoietic stem-cell transplantation in diffuse large B-cell lymphoma with secondary CNS involvement (MARIETTA): an international, single-arm, phase 2 trial |
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| المؤلفون: | Ferreri A. J. M., Doorduijn J. K., Re A., Cabras M. G., Smith J., Ilariucci F., Luppi M., Calimeri T., Cattaneo C., Khwaja J., Botto B., Cellini C., Nassi L., Linton K., McKay P., Olivieri J., Patti C., Re F., Fanni A., Singh V., Bromberg J. E. C., Cozens K., Gastaldi E., Bernardi M., Cascavilla N., Davies A., Fox C. P., Frezzato M., Osborne W., Liberati A. M., Novak U., Zambello R., Zucca E., Cwynarski K. |
| المساهمون: | Ferreri, A. J. M., Doorduijn, J. K., Re, A., Cabras, M. G., Smith, J., Ilariucci, F., Luppi, M., Calimeri, T., Cattaneo, C., Khwaja, J., Botto, B., Cellini, C., Nassi, L., Linton, K., Mckay, P., Olivieri, J., Patti, C., Re, F., Fanni, A., Singh, V., Bromberg, J. E. C., Cozens, K., Gastaldi, E., Bernardi, M., Cascavilla, N., Davies, A., Fox, C. P., Frezzato, M., Osborne, W., Liberati, A. M., Novak, U., Zambello, R., Zucca, E., Cwynarski, K. |
| بيانات النشر: | Elsevier Ltd |
| سنة النشر: | 2021 |
| الوصف: | Background: Secondary CNS lymphoma is a rare but potentially lethal event in patients with diffuse large B-cell lymphoma. We aimed to assess the activity and safety of an intensive, CNS-directed chemoimmunotherapy consolidated by autologous haematopoietic stem-cell transplantation (HSCT) in patients with secondary CNS lymphoma. Methods: This international, single-arm, phase 2 trial was done in 24 hospitals in Italy, the UK, the Netherlands, and Switzerland. Adults (aged 18–70 years) with histologically diagnosed diffuse large B-cell lymphoma and CNS involvement at the time of primary diagnosis or at relapse and Eastern Cooperative Oncology Group Performance Status of 3 or less were enrolled and received three courses of MATRix (rituximab 375 mg/m2, intravenous infusion, day 0; methotrexate 3·5 g/m2, the first 0·5 g/m2 in 15 min followed by 3 g/m2 in a 3 h intravenous infusion, day 1; cytarabine 2 g/m2 every 12 h, in 1 h intravenous infusions, days 2 and 3; thiotepa 30 mg/m2, 30 min intravenous infusion, day 4) followed by three courses of RICE (rituximab 375 mg/m2, day 1; etoposide 100 mg/m2 per day in 500–1000 mL over a 60 min intravenous infusion, days 1, 2, and 3; ifosfamide 5 g/m2 in 1000 mL in a 24 h intravenous infusion with mesna support, day 2; carboplatin area under the curve of 5 in 500 mL in a 1 h intravenous infusion, day 2) and carmustine–thiotepa and autologous HSCT (carmustine 400 mg/m2 in 500 mL glucose 5% solution in a 1–2 h infusion, day −6; thiotepa 5 mg/kg in saline solution in a 2 h infusion every 12 h, days −5 and −4). The primary endpoint was progression-free survival at 1 year. Overall and complete response rates before autologous HSCT, duration of response, overall survival, and safety were the secondary endpoints. Analyses were in the modified intention-to-treat population. This study is registered with ClinicalTrials.gov, NCT02329080. The trial ended after accrual completion; the database lock was Dec 31, 2019. Findings: Between March 30, 2015, and Aug 3, 2018, 79 patients were ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/33513372; info:eu-repo/semantics/altIdentifier/wos/WOS:000614459700010; volume:8; issue:2; firstpage:110; lastpage:121; numberofpages:12; journal:THE LANCET. HAEMATOLOGY; https://hdl.handle.net/20.500.11768/153401Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85099661348; https://www.sciencedirect.com/science/article/pii/S2352302620303665?via=ihubTest |
| DOI: | 10.1016/S2352-3026(20)30366-5 |
| الإتاحة: | https://doi.org/20.500.11768/153401Test https://doi.org/10.1016/S2352-3026Test(20)30366-5 https://hdl.handle.net/20.500.11768/153401Test https://www.sciencedirect.com/science/article/pii/S2352302620303665?via=ihubTest |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.91F1A4E5 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/S2352-3026(20)30366-5 |
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