التفاصيل البيبلوغرافية
| العنوان: |
Shortening of Saccades as a Possible Easy-to-Use Biomarker to Detect Risk of Alzheimer's Disease |
| المؤلفون: |
Hannonen, Sanna, Andberg, Sami, Kärkkäinen, Virve, Rusanen, Minna, Lehtola, Juha-Matti, Saari, Toni, Korhonen, Ville, Hokkanen, Laura, Hallikainen, Merja, Hänninen, Tuomo, Leinonen, Ville, Kaarniranta, Kai, Bednarik, Roman, Koivisto, Anne M. |
| المساهمون: |
Department of Psychology and Logopedics, University of Helsinki, Department of Neurosciences, HUS Neurocenter, Neurologian yksikkö, Geriatrian yksikkö |
| بيانات النشر: |
IOS PRESS |
| سنة النشر: |
2022 |
| المجموعة: |
Helsingfors Universitet: HELDA – Helsingin yliopiston digitaalinen arkisto |
| مصطلحات موضوعية: |
Alzheimer's disease, biomarker, CERAD, eye tracking, King-Devick, mild cognitive impairment, saccadic eye movements, CERAD NEUROPSYCHOLOGICAL BATTERY, KING-DEVICK TEST, ASSOCIATION WORKGROUPS, DIAGNOSTIC GUIDELINES, NATIONAL INSTITUTE, RECOMMENDATIONS, DEMENTIA, ALLELE, 3112 Neurosciences, 3124 Neurology and psychiatry, 515 Psychology, Neuropsychology |
| الوصف: |
Background: Wide-ranging functional defects in eye movements have been reported in Alzheimer's disease (AD) dementia. The detection of abnormal eye movements and reading problems may identify persons at risk of AD when clear clinical symptoms are lacking. Objective: To examine whether computer-based eye-tracking (ET) analysis of King-Devick (KD) test results differentiates cognitively healthy persons from persons with minor problems in cognitive testing or diagnosed mild AD. Methods: We recruited 78 participants (57 non-demented, 21 with mild AD) who underwent neurological examination, the Consortium to Establish a Registry for Alzheimer's Disease neuropsychological test battery (CERAD-NB), and a Clinical Dementia Rating (CDR) interview. The non-demented participants were further divided into control (normal CERAD subtests, mean MMSE= 28) and objective mild cognitive impairment (MCI; decline in at least one CERAD memory score, mean MMSE= 27) groups. The KD reading test was performed using computer-based ET. The total time used for the reading test, errors made, fixation and saccade durations, and saccade amplitudes were analyzed. Results: We found significant differences between the control, objective MCI, and AD groups in regard to the mean saccade amplitude (3.58, 3.33, and 3.21 ms, respectively, p < 0.03) and duration (27.1, 25.3, and 24.8 ms, respectively, p < 0.05). The KD error scores in the AD group differed significantly (p < 0.01) from the other groups. Conclusion: Computed ET analysis of the KD test may help detect persons with objective MCI early when clear clinical symptoms are lacking. The portable device for ET is easy to use in primary health care memory clinics. ; Peer reviewed |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| العلاقة: |
We are deeply grateful to all of the study participants. We also thank BEGAD research project study nurses Ulla Vanhanen, Kati Monttinen, and Kristiina Holopainen for recruiting the study participants. We thank biostatistician Tuomas Selander for help with the statistical analysis. This work was supported by Juho and Lempi Pitkanen Foundation.; Hannonen , S , Andberg , S , Kärkkäinen , V , Rusanen , M , Lehtola , J-M , Saari , T , Korhonen , V , Hokkanen , L , Hallikainen , M , Hänninen , T , Leinonen , V , Kaarniranta , K , Bednarik , R & Koivisto , A M 2022 , ' Shortening of Saccades as a Possible Easy-to-Use Biomarker to Detect Risk of Alzheimer's Disease ' , Journal of Alzheimer's Disease , vol. 88 , no. 2 , pp. 609-618 . https://doi.org/10.3233/JAD-215551Test; ORCID: /0000-0001-8342-9248/work/117173311; cf23b6b3-9995-43a9-a640-5ab028bd110c; http://hdl.handle.net/10138/346799Test; 000828034300020 |
| الإتاحة: |
http://hdl.handle.net/10138/346799Test |
| حقوق: |
cc_by_nc ; openAccess ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: |
edsbas.91C63377 |
| قاعدة البيانات: |
BASE |
