صورة
Treatment of IECs with another NFκB inhibitor increases host cell damage, loss of barrier integrity, and fungal translocation.
| العنوان: | Treatment of IECs with another NFκB inhibitor increases host cell damage, loss of barrier integrity, and fungal translocation. |
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| المؤلفون: | Jakob L. Sprague, Tim B. Schille, Stefanie Allert, Verena Trümper, Adrian Lier, Peter Großmann, Emily L. Priest, Antzela Tsavou, Gianni Panagiotou, Julian R. Naglik, Duncan Wilson, Sascha Schäuble, Lydia Kasper, Bernhard Hube |
| سنة النشر: | 2024 |
| مصطلحات موضوعية: | Medicine, Microbiology, Cell Biology, Molecular Biology, Physiology, Ecology, Immunology, Cancer, Science Policy, Infectious Diseases, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, process remain unclear, microbial mechanisms behind, human mucosal surfaces, full virulence potential, frequently causes infections, div >< p, certain predisposing conditions, opportunistic fungal pathogen, peptide toxin candidalysin, intestinal epithelial barrier, fungal zinc acquisition, intestinal epithelial cells, mediated barrier protection, restrict fungal translocation, candida albicans <, iecs limits candidalysin, iecs counteract damage |
| الوصف: | (A) Inhibition of NFκB activation using the NFκB inhibitor SC75741 at concentrations of either 2.5 or 5 μM increased the damage of WT (BWP17) C . albicans , but not for the ece1 Δ/Δ strains. LDH release was adjusted by subtracting the release from uninfected and untreated host cells. (B) NFκB inhibition using either concentration also decreased the barrier integrity during infection with both WT and ece1 Δ/Δ strains. (C) Fungal translocation was significantly increased during infection with both WT and ece1 Δ/Δ C . albicans upon inhibition of NFκB using both concentrations of SC75741. These results match those obtained with the high-affinity NFκB inhibitor quinazoline. All values are shown as the mean with standard deviation. Host-cell damage (A), barrier integrity (B), and fungal translocation (C) data were compared using a one-way ANOVA with a post-hoc Šidák’s multiple comparisons test. Statistical significance: *, P ≤ 0.05; **, P ≤ 0.01; ***, P ≤ 0.001; ****, P ≤ 0.0001. (TIF) |
| نوع الوثيقة: | still image |
| اللغة: | unknown |
| العلاقة: | https://figshare.com/articles/figure/Treatment_of_IECs_with_another_NF_B_inhibitor_increases_host_cell_damage_loss_of_barrier_integrity_and_fungal_translocation_/25328950Test |
| DOI: | 10.1371/journal.ppat.1012031.s008 |
| الإتاحة: | https://doi.org/10.1371/journal.ppat.1012031.s008Test https://figshare.com/articles/figure/Treatment_of_IECs_with_another_NF_B_inhibitor_increases_host_cell_damage_loss_of_barrier_integrity_and_fungal_translocation_/25328950Test |
| حقوق: | CC BY 4.0 |
| رقم الانضمام: | edsbas.91BB48AB |
| قاعدة البيانات: | BASE |
| DOI: | 10.1371/journal.ppat.1012031.s008 |
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