دورية أكاديمية
ACTIVATION OF MUSCARINIC CHOLINERGIC RECEPTORS STIMULATES INOSITOL PHOSPHATES SYNTHESIS IN THE DEVELOPING AVIAN COCHLEAR DUCT
| العنوان: | ACTIVATION OF MUSCARINIC CHOLINERGIC RECEPTORS STIMULATES INOSITOL PHOSPHATES SYNTHESIS IN THE DEVELOPING AVIAN COCHLEAR DUCT |
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| المؤلفون: | Bartolami, Sylvain, Mayat, Ebrahim, Lippe, William, R, Rebillard, Guy, Pujol, Remy |
| المساهمون: | Neurobiologie de l'audition-plasticité synaptique, Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM) |
| المصدر: | ISSN: 0736-5748 ; International Journal of Developmental Neuroscience ; https://hal.science/hal-02163286Test ; International Journal of Developmental Neuroscience, 1992, 10, pp.31 - 36. |
| بيانات النشر: | HAL CCSD Elsevier |
| سنة النشر: | 1992 |
| المجموعة: | Inserm: HAL (Institut national de la santé et de la recherche médicale) |
| مصطلحات موضوعية: | cochlear duct, inositol phosphates, muscarinic cholinergic receptors, [SDV]Life Sciences [q-bio], [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] |
| الوصف: | International audience ; We previously reported that the inositol phosphates (IPs) synthesis is induced by muscarinic agonists in the rat cochlea and that this stimulation is maximal at postnatal day 12. This peak response is concomitant with the onset of the efferent synaptogenesis at the outer hair cell level. Whether the correlation between this neuronal plasticity and the enhanced IPs formation is unique to the rat or a general feature of the developing vertebrate cochlea is not known. To examine this question, we measured, in the presence of LiCI, the accumulation of (3H)-IPs induced by carbachol, in the developing chick cochlear duct during a period ranging from embryonic day (E) 8 to post-hatching day (P) 20. Carbachol (1 mM) causes a significant increase of IPs formation relative to basal values at all ages. This IPs accumulation is maximal at E8 (1854% of the basal level), then, rapidly decreases until P13 when it reaches a steady-state level of 294% of the basal level. Strikingly, this gradual decline in IPs formation is interrupted between El5 and El9, by a transient increase in IPs synthesis. This rise peaks at El6 with a stimulation value of 757% of the control level. This maximal stimulation is inhibited by atropine in a dose-dependent manner, as is the case at E9, suggesting the involvement of muscarinic receptors. Interestingly, the occurrence of the peak response is concomitant with the plastic events associated with the maturation of the efferent innervation of the cochlear duct. Thus, these results suggest that there may be a correlation between cochlear plasticity and enhanced IPs synthesis, which is not species-specific. The possible significance of the overall decrease in IPs formation, occurring during embryonic development , is discussed. The degradation of membrane phosphatidylinositol 4,5 biphosphate, by the enzyme phospholi-pase C, leads to the formation of diacylglycerol and inositol phosphates (IPs). Among these metabolites, diacylglycerol and inositol 1,4,5-trisphosphate are ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | hal-02163286; https://hal.science/hal-02163286Test; https://hal.science/hal-02163286/documentTest; https://hal.science/hal-02163286/file/1-s2.0-073657489290004J-main.pdfTest |
| الإتاحة: | https://hal.science/hal-02163286Test https://hal.science/hal-02163286/documentTest https://hal.science/hal-02163286/file/1-s2.0-073657489290004J-main.pdfTest |
| حقوق: | info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.91A738D7 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |