دورية أكاديمية
Prostaglandin F2 α upregulates Slit/Robo expression in mouse corpus luteum during luteolysis
| العنوان: | Prostaglandin F2 α upregulates Slit/Robo expression in mouse corpus luteum during luteolysis |
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| المؤلفون: | Zhang, XueJing, Li, JianHua, Liu, JiaLi, Luo, HaoShu, Gou, KeMian, Cui, Sheng |
| المصدر: | Journal of Endocrinology ; volume 218, issue 3, page 299-310 ; ISSN 0022-0795 1479-6805 |
| بيانات النشر: | Bioscientifica |
| سنة النشر: | 2013 |
| الوصف: | Prostaglandin F 2 α (PGF 2 α ) is a key factor in the triggering of the regression of the corpus luteum (CL). Furthermore, it has been reported that Slit/Robo signaling is involved in the regulation of luteolysis. However, the interactions between PGF 2 α and Slit/Robo in the progression of luteolysis remain to be established. This study was designed to determine whether luteolysis is regulated by the interactions of PGF 2 α and Slit/Robo in the mouse CL. Real-time PCR and immunohistochemistry results showed that Slit2 and its receptor Robo1 are highly and specifically co-expressed in the mouse CL. Functional studies showed that Slit/Robo participates in mouse luteolysis by enhancing cell apoptosis and upregulating caspase3 expression. Both in vitro and in vivo studies showed that PGF 2 α significantly increases the expression of Slit2 and Robo1 during luteolysis through protein kinase C-dependent ERK1/2 and P38 MAPK signaling pathways, whereas an inhibitor of Slit/Robo signaling significantly decreases the stimulating effect of PGF 2 α on luteolysis. These findings indicate that Slit/Robo signaling plays important roles in PGF 2 α -induced luteolysis by mediating the PGF 2 α signaling pathway in the CL. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| DOI: | 10.1530/joe-13-0088 |
| الإتاحة: | https://doi.org/10.1530/joe-13-0088Test https://joe.bioscientifica.com/view/journals/joe/218/3/299.xmlTest https://joe.bioscientifica.com/downloadpdf/journals/joe/218/3/299.xmlTest |
| رقم الانضمام: | edsbas.9186221E |
| قاعدة البيانات: | BASE |
| DOI: | 10.1530/joe-13-0088 |
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