دورية أكاديمية
Development of delivery system based on marine chitosan: Encapsulationand release kinetic study of antioxidant peptides from chitosan microparticle
| العنوان: | Development of delivery system based on marine chitosan: Encapsulationand release kinetic study of antioxidant peptides from chitosan microparticle |
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| المؤلفون: | Nasri, Rim, Hamdi, Marwa, Touir, Sana, Li, S.M., Karra-Chaâbouni, Maha, Nasri, Moncef |
| المساهمون: | Université de Sfax - University of Sfax, Université de Monastir - University of Monastir (UM), Institut Européen des membranes (IEM), Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Institut de Chimie - CNRS Chimie (INC-CNRS)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS) |
| المصدر: | ISSN: 0141-8130 ; International Journal of Biological Macromolecules ; https://hal.science/hal-04207515Test ; International Journal of Biological Macromolecules, 2021, 167, pp.1445-1451. ⟨10.1016/j.ijbiomac.2020.11.098⟩. |
| بيانات النشر: | HAL CCSD Elsevier |
| سنة النشر: | 2021 |
| المجموعة: | Université de Montpellier: HAL |
| مصطلحات موضوعية: | Antioxidant activity, Biopeptides, Chitosan microparticles, Delivery system, Encapsulation, Kinetic release, MESH: Animals, MESH: Anions, MESH: Kinetics, MESH: Microscopy, Electron, Scanning, MESH: Particle Size, MESH: Peptides, MESH: Polyphosphates, MESH: Protein Hydrolysates, MESH: Spectroscopy, Fourier Transform Infrared, MESH: Thermogravimetry, MESH: Antioxidants, MESH: Brachyura, MESH: Capsules, MESH: Chitosan, MESH: Diffusion, MESH: Drug Delivery Systems, MESH: Fishes, MESH: Hot Temperature, [CHIM.POLY]Chemical Sciences/Polymers, [SDV.SP.PG]Life Sciences [q-bio]/Pharmaceutical sciences/Galenic pharmacology, [SDV.SP.PHARMA]Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology |
| الوصف: | International audience ; The present work aims to encapsulate goby fish protein hydrolysate (GPH), endowed with antioxidant activity, through ionic gelation process using blue crab chitosan (CH) and tripolyphosphate anions and to evaluate the structural, thermal and antioxidant properties of the elaborated microparticles (MPs). The GPH-loaded MPs present spherical shape as seen by scanning electron microscopy (SEM) images and positive zeta potential. The increase of loaded GPH concentration led to the increase of encapsulation efficiency (EE) and to the reduction of the particle size. In fact, MPs, loaded with 2 and 5 mg/ml GPH, had EE values of 44 and 58% and mean particles size of 4.81 and 3.78 μm, respectively. Furthermore, thermogravimetric analysis (TGA) profiles revealed the enhanced thermal stability of encapsulated biopeptides compared to the free ones. Release kinetic data showed a Fickian diffusion behavior which follows swelling and a diffusion-controlled mechanism for peptides liberation. Finally, as opposed to unloaded MPs, an improvement of the antioxidant activity of the loaded MPs with biopeptides was observed. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/33212105; hal-04207515; https://hal.science/hal-04207515Test; https://hal.science/hal-04207515/documentTest; https://hal.science/hal-04207515/file/SOUS%20COP_Li20-Rim-Int%20J%20Biol%20Mac.pdfTest; PUBMED: 33212105; WOS: 000606683200129 |
| DOI: | 10.1016/j.ijbiomac.2020.11.098 |
| الإتاحة: | https://doi.org/10.1016/j.ijbiomac.2020.11.098Test https://hal.science/hal-04207515Test https://hal.science/hal-04207515/documentTest https://hal.science/hal-04207515/file/SOUS%20COP_Li20-Rim-Int%20J%20Biol%20Mac.pdfTest |
| حقوق: | http://creativecommons.org/licenses/by-nc-ndTest/ ; info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.91711080 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.ijbiomac.2020.11.098 |
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