التفاصيل البيبلوغرافية
| العنوان: |
Neutrophils Regulate Humoral Autoimmunity by Restricting Interferon-γ Production via the Generation of Reactive Oxygen Species |
| المؤلفون: |
Huang, Xinfang, Li, Jingjing, Dorta-Estremera, Stephanie, Di Domizio, Jeremy, Anthony, Scott M, Watowich, Stephanie S, Popkin, Daniel, Liu, Zheng, Brohawn, Philip, Yao, Yihong, Schluns, Kimberly S, Lanier, Lewis L, Cao, Wei |
| المصدر: |
Cell Reports, vol 12, iss 7 |
| بيانات النشر: |
eScholarship, University of California |
| سنة النشر: |
2015 |
| المجموعة: |
University of California: eScholarship |
| مصطلحات موضوعية: |
Biochemistry and Cell Biology, Biological Sciences, Autoimmune Disease, Lupus, Aetiology, 2.1 Biological and endogenous factors, Inflammatory and immune system, Animals, Autoimmunity, B-Lymphocytes, Dendritic Cells, Female, Immunity, Humoral, Interferon-gamma, Interleukin-15, Killer Cells, Natural, Lupus Erythematosus, Systemic, Male, Mice, Inbred BALB C, Inbred C57BL, Neutrophils, Reactive Oxygen Species, Medical Physiology |
| الوقت: |
1120 - 1132 |
| الوصف: |
Here, we examine the mechanism by which plasmacytoid dendritic cells (pDCs) and type I interferons promote humoral autoimmunity. In an amyloid-induced experimental autoimmune model, neutrophil depletion enhanced anti-nuclear antibody development, which correlated with heightened IFN-γ production by natural killer (NK) cells. IFN-α/β produced by pDCs activated NK cells via IL-15 induction. Neutrophils released reactive oxygen species (ROS), which negatively modulated the levels of IL-15, thereby inhibiting IFN-γ production. Mice deficient in NADPH oxidase 2 produced increased amounts of IFN-γ and developed augmented titers of autoantibodies. Both the pDC-IFN-α/β pathway and IFN-γ were indispensable in stimulating humoral autoimmunity. Male NZB/W F1 mice expressed higher levels of superoxide than their female lupus-prone siblings, and depletion of neutrophils resulted in spontaneous NK cell and autoimmune B cell activation. Our findings suggest a regulatory role for neutrophils in vivo and highlight the importance of an NK-IFN-γ axis downstream of the pDC-IFN-α/β pathway in systemic autoimmunity. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
unknown |
| العلاقة: |
qt9tc326sq; https://escholarship.org/uc/item/9tc326sqTest |
| الإتاحة: |
https://escholarship.org/uc/item/9tc326sqTest |
| حقوق: |
public |
| رقم الانضمام: |
edsbas.9166A7B8 |
| قاعدة البيانات: |
BASE |
