التفاصيل البيبلوغرافية
| العنوان: |
Genetic, cellular, and connectomic characterization of the brain regions commonly plagued by glioma |
| المؤلفون: |
Mandal, Ayan, Romero García, Rafael, Hart, Michael G., Suckling, John |
| المساهمون: |
Universidad de Sevilla. Departamento de Fisiología Médica y Biofísica, Universidad de Sevilla. CTS1086: Psiquiatría Traslacional |
| بيانات النشر: |
Oxford University Press |
| سنة النشر: |
2023 |
| المجموعة: |
idUS - Deposito de Investigación Universidad de Sevilla |
| مصطلحات موضوعية: |
Neuro-oncology, Gliomagenesis, Connectomics, Imaging-transcriptomics |
| الوصف: |
For decades, it has been known that gliomas follow a non-random spatial distribution, appearing more often in some brain regions (e.g. the insula) compared to others (e.g. the occipital lobe). A better understanding of the localization patterns of gliomas could provide clues to the origins of these types of tumours, and consequently inform treatment targets. Following hypotheses derived from prior research into neuropsychiatric disease and cancer, gliomas may be expected to localize to brain regions characterized by functional hubness, stem-like cells, and transcription of genetic drivers of gliomagenesis. We combined neuroimaging data from 335 adult patients with high- and low-grade glioma to form a replicable tumour frequency map. Using this map, we demonstrated that glioma frequency is elevated in association cortex and correlated with multiple graph-theoretical metrics of high functional connectedness. Brain regions populated with putative cells of origin for glioma, neural stem cells and oligodendrocyte precursor cells, exhibited a high glioma frequency. Leveraging a human brain atlas of post-mortem gene expression, we found that gliomas were localized to brain regions enriched with expression of genes associated with chromatin organization and synaptic signalling. A set of glioma proto-oncogenes was enriched among the transcriptomic correlates of glioma distribution. Finally, a regression model incorporating connectomic, cellular, and genetic factors explained 58% of the variance in glioma frequency. These results add to previous literature reporting the vulnerability of hub regions to neurological disease, as well as provide support for cancer stem cell theories of glioma. Our findings illustrate how factors of diverse scale, from genetic to connectomic, can independently in fluence the anatomic localization of brain dysfunction. ; Bill and Melinda Gates Foundation OPP1144 ; Brain fellowship ; Gates Cambridge Scholarship ; Medical Research Council (MRC) MR/M009041/1 ; MRC MR/M009041/1 |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| العلاقة: |
Brain, 143 (11), 3294-3307.; https://idus.us.es/handle//11441/147025Test |
| الإتاحة: |
https://idus.us.es/handle//11441/147025Test |
| حقوق: |
Atribución 4.0 Internacional ; http://creativecommons.org/licenses/by/4.0Test/ ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: |
edsbas.9148ED1A |
| قاعدة البيانات: |
BASE |
