دورية أكاديمية
Shared genetic risk between eating disorder- and substance-use-related phenotypes: Evidence from genome-wide association studies
| العنوان: | Shared genetic risk between eating disorder- and substance-use-related phenotypes: Evidence from genome-wide association studies |
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| المؤلفون: | Munn-Chernoff, Melissa, A, Johnson, Emma, C, Chou, Yi-Ling, Coleman, Jonathan R.I., Thornton, Laura, Walters, Raymond, K, Yilmaz, Zeynep, Baker, Jessica, H, Hübel, Christopher, Gordon, Scott, Medland, Sarah, Watson, Hunna, Gaspar, Héléna, Bryois, Julien, Hinney, Anke, Leppä, Virpi, Mattheisen, Manuel, Ripke, Stephan, Yao, Shuyang, Giusti-Rodríguez, Paola, Hanscombe, Ken, B, Adan, Roger A.H., Alfredsson, Lars, Ando, Tetsuya, Andreassen, Ole, A, Berrettini, Wade, Boehm, Ilka, Boni, Claudette, Boraska Perica, Vesna, Buehren, Katharina, Burghardt, Roland, Cassina, Matteo, Cichon, Sven, Clementi, Maurizio, Cone, Roger, Courtet, Philippe, Crow, Scott, Crowley, James, Danner, Unna, Davis, Oliver S.P., de Zwaan, Martina, Dedoussis, George, Degortes, Daniela, Desocio, Janiece, Dick, Danielle, Dikeos, Dimitris, Dina, Christian, Dmitrzak-Weglarz, Monika, Docampo, Elisa, Duncan, Laramie, Egberts, Karin, Ehrlich, Stefan, Escaramís, Geòrgia, Esko, Tõnu, Estivill, Xavier, Farmer, Anne, E., Favaro, Angela, Fernández-Aranda, Fernando, Fichter, Manfred, Fischer, Krista, Föcker, Manuel, Foretova, Lenka, Forstner, Andreas, Forzan, Monica, Franklin, Christopher, Gallinger, Steven, Giegling, Ina, Giuranna, Johanna, Gonidakis, Fragiskos, Gorwood, Philip, Gratacos Mayora, Monica, Guillaume, Sébastien, Guo, Yiran, Hakonarson, Hakon, Hatzikotoulas, Konstantinos, Hauser, Joanna, Hebebrand, Johannes, Helder, Sietske, Herms, Stefan, Herpertz-Dahlmann, Beate, Herzog, Wolfgang, Huckins, Laura, Hudson, James, E, Imgart, Hartmut, Inoko, Hidetoshi, Janout, Vladimír, Jiménez-Murcia, Susana, Julià, Antonio, Kalsi, Gursharan, Kaminská, Deborah, Karhunen, Leila, Karwautz, Andreas, Kas, Martien J.H., Kennedy, James, Keski-Rahkonen, Anna, Kiezebrink, Kirsty, Kim, Youl-Ri, Klump, Kelly, Knudsen, Gun Peggy S., La Via, Maria, Le Hellard, Stephanie, Levitan, Robert, Li, Dong, Lilenfeld, Lisa, Lin, Bochao Danae, Lissowska, Jolanta, Luykx, Jurjen, Magistretti, Pierre, J., Maj, Mario, Männik, Katrin, Marsal, Sara, Marshall, Christian, R., Mattingsdal, Morten, Mcdevitt, Sara, Mcguffin, Peter, Metspalu, Andres, Meulenbelt, Ingrid, Micali, Nadia, Mitchell, Karen, Monteleone, Alessio Maria, Monteleone, Palmiero, Nacmias, Benedetta, Navratilova, Marie, Ntalla, Ioanna, O'Toole, Julie, Ophoff, Roel, A., Padyukov, Leonid, Palotie, Aarno, Pantel, Jacques, Papezova, Hana, Pinto, Dalila, Rabionet, Raquel, Raevuori, Anu, Ramoz, Nicolas, Reichborn-Kjennerud, Ted, Ricca, Valdo, Ripatti, Samuli, Ritschel, Franziska, Roberts, Marion, Rotondo, Alessandro, Rujescu, Dan, Rybakowski, Filip, Santonastaso, Paolo, Scherag, Andre, Scherer, Stephen, W., Schmidt, Ulrike, Schork, Nicholas, J., Schosser, Alexandra, Seitz, Jochen, Slachtova, Lenka, Slagboom, P. Eline, Slof-Op'T Landt, Margarita C.T., Slopien, Agnieszka, Sorbi, Sandro, Świątkowska, Beata, Szatkiewicz, Jin, Tachmazidou, Ioanna, Tenconi, Elena, Tortorella, Alfonso, Tozzi, Federica, Treasure, Janet, Tsitsika, Artemis, Tyszkiewicz-Nwafor, Marta, Tziouvas, Konstantinos, van Elburg, Annemarie, van Furth, Eric, Wagner, Gudrun, Walton, Esther, Widén, Elisabeth, Zeggini, Eleftheria, Zerwas, Stephanie, Zipfel, Stephan, Bergen, Andrew, Boden, Joseph, Brandt, Harry, Crawford, Steven, Halmi, Katherine, Horwood, L. John, Johnson, Craig, Kaplan, Allan, Mitchell, James, Brian Alexander, Kaye, Walter, Olsen, Catherine, Pearson, John, Pedersen, Nancy, L., Strober, Michael, Werge, Thomas, Whiteman, David, C, Woodside, D. Blake, Grove, Jakob, Henders, Anjali, K., Larsen, Janne, Parker, Richard, Petersen, Liselotte, Jordan, Jennifer, Kennedy, Martin, Birgegård, Andreas, Lichtenstein, Paul, Norring, Claes, Landén, Mikael, Mortensen, Preben Bo, Polimanti, Renato, Mcclintick, Jeanette, Adkins, Amy, Aliev, Fazil, Bacanu, Silviu-Alin, Batzler, Anthony, Bertelsen, Sarah, Biernacka, Joanna, M., Bigdeli, Tim, Chen, Li-Shiun, Clarke, Toni-Kim, Degenhardt, Franziska, Docherty, Anna, Edwards, Alexis, Foo, Jerome, Fox, Louis, Frank, Josef, Hack, Laura, Hartmann, Annette, M., Hartz, Sarah, Heilmann-Heimbach, Stefanie, Hodgkinson, Colin, Hoffmann, Per, Hottenga, Jouke-Jan, Konte, Bettina, Lahti, Jari, Lahti-Pulkkinen, Marius, Lai, Dongbing, Ligthart, Lannie, Loukola, Anu, Maher, Brion, Mbarek, Hamdi, Mcintosh, Andrew, Mcqueen, Matthew, Meyers, Jacquelyn, Milaneschi, Yuri, Palviainen, Teemu, Peterson, Roseann, Ryu, Euijung, Saccone, Nancy, Salvatore, Jessica, Sanchez-Roige, Sandra, Schwandt, Melanie, Sherva, Richard, Streit, Fabian, Strohmaier, Jana, Thomas, Nathaniel, Wang, Jen-Chyong, Webb, Bradley, Wedow, Robbee, Wetherill, Leah, Wills, Amanda, Zhou, Hang, Boardman, Jason, Chen, Danfeng, Choi, Doo-Sup, Copeland, William, Culverhouse, Robert, Dahmen, Norbert, Degenhardt, Louisa, Domingue, Benjamin, Frye, Mark, A., Gäbel, Wolfgang, Hayward, Caroline, Ising, Marcus, Keyes, Margaret, Kiefer, Falk, Koller, Gabriele, Kramer, John, Kuperman, Samuel, Lucae, Susanne, Lynskey, Michael, Maier, Wolfgang, Mann, Karl, Männistö, Satu, Müller-Myhsok, Bertram, Murray, Alison, Nurnberger, John, I., Preuss, Ulrich, Räikkönen, Katri, Reynolds, Maureen, Ridinger, Monika, Scherbaum, Norbert, Schuckit, Marc, Soyka, Michael, Treutlein, Jens, Witt, Stephanie, Wodarz, Norbert, Zill, Peter, Adkins, Daniel, Boomsma, Dorret, Bierut, Laura, J., Brown, Sandra, Bucholz, Kathleen, Costello, E. Jane, de Wit, Harriet, Diazgranados, Nancy, Eriksson, Johan, Farrer, Lindsay, Foroud, Tatiana, Gillespie, Nathan, Goate, Alison, Goldman, David, Grucza, Richard, Hancock, Dana, B., Harris, Kathleen Mullan, Hesselbrock, Victor, Hewitt, John, Hopfer, Christian, Iacono, William, Johnson, Eric, Karpyak, Victor, Kendler, Kenneth, Kranzler, Henry, Krauter, Kenneth, Lind, Penelope, Mcgue, Matt, Mackillop, James, Madden, Pamela A.F., Maes, Hermine, Magnusson, Patrik K.E., Nelson, Elliot, Nöthen, Markus, M., Palmer, Abraham, Penninx, Brenda W.J.H., Porjesz, Bernice, Rice, John, P., Rietschel, Marcella, Riley, Brien, Rose, Richard, J., Shen, Pei-Hong, Silberg, Judy, Stallings, Michael, Tarter, Ralph, Vanyukov, Michael, Vrieze, Scott, Wall, Tamara, Whitfield, John, Zhao, Hongyu, Neale, Benjamin, M., Wade, Tracey, Heath, Andrew, Montgomery, Grant, W., Martin, Nicholas, M, Sullivan, Patrick, Kaprio, Jaakko, Breen, Gerome, Gelernter, Joel, Edenberg, Howard, J., Bulik, Cynthia, Agrawal, Arpana |
| المساهمون: | University of North Carolina Chapel Hill (UNC), University of North Carolina System (UNC), Department Psychiatry Chapel Hill, University of North Carolina System (UNC)-University of North Carolina System (UNC), Washington University School of Medicine in St. Louis, Washington University in Saint Louis (WUSTL), Institute of Psychiatry, Psychology & Neuroscience, King's College London, King‘s College London, Harvard Medical School Boston (HMS), Broad Institute of MIT and Harvard (BROAD INSTITUTE), Harvard Medical School Boston (HMS)-Massachusetts Institute of Technology (MIT)-Massachusetts General Hospital Boston, QIMR Berghofer Medical Research Institute, Karolinska Institutet Stockholm, University Children's Hospital of Essen, University Hospital Essen (AöR), Universität Duisburg-Essen = University of Duisburg-Essen Essen, Aarhus University Aarhus, Stockholm County Council, University of Würzburg, Guy's Hospital London, University Medical Center Utrecht, Göteborgs Universitet = University of Gothenburg (GU), Altrecht Center for Eating Disorders Rintveld Zeist, The Netherlands (Mental Health Institute), National Institute of Mental Health (NIMH), National Center of Neurology and Psychiatry Tokyo, Japan, University of Oslo (UiO), Norwegian Centre for Mental Disorders Research Oslo (NORMENT), University of Oslo (UiO)-Haukeland University Hospital, University of Bergen (UiB)-University of Bergen (UiB)-Oslo University Hospital Oslo, Department of Psychiatry Philadelphia, University of Pennsylvania, Perelman School of Medicine, Technische Universität Dresden = Dresden University of Technology (TU Dresden), Centre de Psychiatrie et Neurosciences (U894), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), University of Split, The Wellcome Trust Sanger Institute Cambridge, Rheinisch-Westfälische Technische Hochschule Aachen University (RWTH), Universitätsklinikum Frankfurt, Università degli Studi di Padova = University of Padua (Unipd), University Hospital Basel Basel, Jülich Supercomputing Centre (JSC), Forschungszentrum Jülich GmbH, Helmholtz-Gemeinschaft = Helmholtz Association-Helmholtz-Gemeinschaft = Helmholtz Association, Centre Hospitalier Régional Universitaire Montpellier (CHRU Montpellier), Neuropsychiatrie : recherche épidémiologique et clinique (PSNREC), Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), University of Minnesota System (UMN), University of Bristol Bristol, Medizinische Hochschule Hannover = Hannover Medical School (MHH), Harokopio University of Athens, Seattle University Seattle, Virginia Commonwealth University (VCU), University of Athens Medical School Athens, ITX - unité de recherche de l'institut du thorax (ITX), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN), Poznan University of Medical Sciences Poland (PUMS), Institute of Environmental Science and Technology Barcelona (ICTA), Universitat Autònoma de Barcelona = Autonomous University of Barcelona = Universidad Autónoma de Barcelona (UAB), Massachusetts General Hospital Boston, Stanford University, MetaGenoPolis (MGP (US 1367)), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Estonian Genome and Medicine, University of Tartu, Universitat Pompeu Fabra Barcelona (UPF), MRC Social, Genetic and Developmental Psychiatry Centre (SGDP), King‘s College London-The Institute of Psychiatry, Institut d'Investigació Biomèdica de Bellvitge = Bellvitge Biomedical Research Institute (IDIBELL), Ludwig Maximilian University Munich = Ludwig Maximilians Universität München (LMU), Infectious diseases division, Department of internal medicine, Westfälische Wilhelms-Universität Münster = University of Münster (WWU), Masaryk Memorial Cancer Institute (MMCI), Universitätsklinikum Bonn (UKB), Familial Gastrointestinal Cancer Registry, Mount Sinai Hospital Toronto, Canada (MSH), Medstar Research Institute, National and Kapodistrian University of Athens (NKUA), Children’s Hospital of Philadelphia (CHOP ), The Center for Applied Genomics, Psychiatric Genetic Unit, Poznan University of Medical Sciences, Department of Child and Adolescent Psychiatry, Centre for Epidemiology and Biostatistics, Faculty of Medicine and Health Leeds, University of Leeds, Heidelberg University Hospital Heidelberg, Icahn School of Medicine at Mount Sinai New York (MSSM), School of Biomedical Sciences, The University of Queensland, Brisbane, QLD, 4072, Australia., Parkland-Klinik Bad Wildungen-Reinhardshausen, Germany, Tokai University, Department of Epidemiology and Public Health university of Ostrava, Lékařská fakulta / Faculty of Medicine University of Ostrava |
| المصدر: | ISSN: 1355-6215. |
| بيانات النشر: | HAL CCSD Wiley |
| سنة النشر: | 2020 |
| المجموعة: | HAL Lyon 1 (University Claude Bernard Lyon 1) |
| مصطلحات موضوعية: | eating disorders, genetic correlation, substance use, [SCCO]Cognitive science, [SCCO.NEUR]Cognitive science/Neuroscience, [SDV]Life Sciences [q-bio], [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, [SDV.MHEP.PSM]Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health |
| الوصف: | International audience ; Eating disorders and substance use disorders frequently co-occur. Twin studies reveal shared genetic variance between liabilities to eating disorders and substance use, with the strongest associations between symptoms of bulimia nervosa and problem alcohol use (genetic correlation [rg ], twin-based = 0.23-0.53). We estimated the genetic correlation between eating disorder and substance use and disorder phenotypes using data from genome-wide association studies (GWAS). Four eating disorder phenotypes (anorexia nervosa [AN], AN with binge eating, AN without binge eating, and a bulimia nervosa factor score), and eight substance-use-related phenotypes (drinks per week, alcohol use disorder [AUD], smoking initiation, current smoking, cigarettes per day, nicotine dependence, cannabis initiation, and cannabis use disorder) from eight studies were included. Significant genetic correlations were adjusted for variants associated with major depressive disorder and schizophrenia. Total study sample sizes per phenotype ranged from ~2400 to ~537 000 individuals. We used linkage disequilibrium score regression to calculate single nucleotide polymorphism-based genetic correlations between eating disorder- and substance-use-related phenotypes. Significant positive genetic associations emerged between AUD and AN (rg = 0.18; false discovery rate q = 0.0006), cannabis initiation and AN (rg = 0.23; q < 0.0001), and cannabis initiation and AN with binge eating (rg = 0.27; q = 0.0016). Conversely, significant negative genetic correlations were observed between three nondiagnostic smoking phenotypes (smoking initiation, current smoking, and cigarettes per day) and AN without binge eating (rgs = -0.19 to -0.23; qs < 0.04). The genetic correlation between AUD and AN was no longer significant after co-varying for major depressive disorder loci. The patterns of association between eating disorder- and substance-use-related phenotypes highlights the potentially complex and substance-specific relationships ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/32064741; inserm-02881410; https://inserm.hal.science/inserm-02881410Test; https://inserm.hal.science/inserm-02881410/documentTest; https://inserm.hal.science/inserm-02881410/file/Addiction%20Biology%20%28Munn-Chernoff,%20PRS%20AN%20and%20AUD%29.pdfTest; PUBMED: 32064741; WOS: 000513571200001 |
| DOI: | 10.1111/adb.12880 |
| الإتاحة: | https://doi.org/10.1111/adb.12880Test https://inserm.hal.science/inserm-02881410Test https://inserm.hal.science/inserm-02881410/documentTest https://inserm.hal.science/inserm-02881410/file/Addiction%20Biology%20%28Munn-Chernoff,%20PRS%20AN%20and%20AUD%29.pdfTest |
| رقم الانضمام: | edsbas.91457CB0 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1111/adb.12880 |
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