دورية أكاديمية
Off-label drugs in childhood psoriasis ; Prescriptions hors AMM (autorisation de mise sur le marché) dans le psoriasis de l'enfant
| العنوان: | Off-label drugs in childhood psoriasis ; Prescriptions hors AMM (autorisation de mise sur le marché) dans le psoriasis de l'enfant |
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| المؤلفون: | Mahé, Emmanuel, Corgibet, Florence, Maccari, François, Hadj-Rabia, Smaïl, Phan, Céline, Ruer-Mulard, Mireille, Boralévi, Franck, Barbarot, Sébastien, Bursztejn, Anne Claire, Lahfa, Mourad, Severino-Freire, Maëlla, Aubin, Françcois J., Barthélémy, Hugues, Amy de La Bretêque, Maud, Beauchet, Alain |
| المساهمون: | Service de Dermatologie - Centre Hospitalier Victor Dupouy, Fédération Hospitalière de France, Imagine - Institut des maladies génétiques (IHU) (Imagine - U1163), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Hôpital Pellegrin, CHU Bordeaux-Groupe hospitalier Pellegrin, Hôtel-Dieu de Nantes, Physiopathologie des Adaptations Nutritionnelles (PhAN), Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), Centre hospitalier d'Auxerre (CHA), Hôpital Victor Dupouy, Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Université de Versailles Saint-Quentin-en-Yvelines - UFR Sciences de la santé Simone Veil (UVSQ Santé), Les auteurs tenaient ? remercier les investigateurs des 3 ?tudes. |
| المصدر: | ISSN: 0151-9638 ; Annales de Dermatologie et de Vénéréologie ; https://hal.science/hal-02927542Test ; Annales de Dermatologie et de Vénéréologie, 2020, 147 (6-7), pp.429-438. ⟨10.1016/j.annder.2020.01.021⟩. |
| بيانات النشر: | HAL CCSD Elsevier Masson |
| سنة النشر: | 2020 |
| المجموعة: | Université de Versailles Saint-Quentin-en-Yvelines: HAL-UVSQ |
| مصطلحات موضوعية: | Adolescent, Child, Cohorts, Infant, Off-label prescriptions, Psoriasis, [SDV]Life Sciences [q-bio] |
| الوصف: | International audience ; Introduction: Psoriasis affects 0.5% of children in Europe, with moderate to severe clinical forms in 15–35% of cases warranting the use of systemic treatments. Few treatments are licensed for childhood psoriasis. In this study, we analyzed the frequency of such prescriptions. Materials and methods: Our study was based on 3 retrospective cohort trials conducted in France between 2012 and 2018: χ-Psocar (313 children with psoriasis seen in hospitals), PsoLib (207 children seen in a private practice), and BiPe (134 children on biotherapies). Our evaluation was centered on off-label use. To avoid duplicates between cohorts, analysis focused on each cohort independently. Results: In the χ-Psocar study, in 34.8% of cases, use of at least one off-label treatment, mainly topical vitamin D (36.0%), and systemic treatments (methotrexate and cyclosporine) was noted, on account of either the clinical type of psoriasis (13.7%) or patient age (24.6%). In the PsoLib study, in 41.5% of cases, at least one off-label treatment was noted, mainly combined calcipotriol-betamethasone (24.2%), ciclopirox shampoo (7.2%) and systemic treatments (n = 20). The main reason was patient age (41.5%). In the BiPe study, in 97.0% of cases, at least one off-label treatment was noted. These prescriptions mainly concerned a combination of calcipotriol-betamethasone (68.7%) and tacrolimus (11.2%) along with systemic treatment comprising methotrexate, cyclosporin, methoxsalen or apremilast (n = 125), but also biotherapies (n = 85). The biotherapies were used off-label since at that time they had not yet been granted marketing authorisation. Discussion: This study focused on 3 cohorts of children with psoriasis seen either in private practice or in a hospital setting, and it involved all types of treatment. Off-label prescriptions ranged from one-third to almost 100% of the children, depending on the individual cohorts. The prescribed drugs were topical treatments, conventional systemic drugs and biotherapies. Off-label ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/32299624; hal-02927542; https://hal.science/hal-02927542Test; PUBMED: 32299624 |
| DOI: | 10.1016/j.annder.2020.01.021 |
| الإتاحة: | https://doi.org/10.1016/j.annder.2020.01.021Test https://hal.science/hal-02927542Test |
| رقم الانضمام: | edsbas.9111EFD1 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.annder.2020.01.021 |
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