صورة
Image_1_FDG-PET-based neural correlates of Addenbrooke’s cognitive examination III scores in Alzheimer’s disease and frontotemporal degeneration.JPEG
| العنوان: | Image_1_FDG-PET-based neural correlates of Addenbrooke’s cognitive examination III scores in Alzheimer’s disease and frontotemporal degeneration.JPEG |
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| المؤلفون: | María Nieves Cabrera-Martín, Pedro Nespral, Maria Valles-Salgado, Pablo Bascuñana, Cristina Delgado-Alonso, Alfonso Delgado-Álvarez, Lucía Fernández-Romero, Juan Ignacio López-Carbonero, María Díez-Cirarda, María José Gil-Moreno, Jorge Matías-Guiu, Jordi A. Matias-Guiu |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | Applied Psychology, Clinical Psychology, Developmental and Educational Psychology, Neuroscience and Physiological Psychology, Organizational Behavioral Psychology, Personality, Social and Criminal Psychology, Gender Psychology, Health, Clinical and Counselling Psychology, Industrial and Organisational Psychology, Psychology not elsewhere classified, Psychology and Cognitive Sciences not elsewhere classified, Alzheimer’s disease, frontotemporal dementia, neuropsychological assessment, Addenbrooke’s cognitive examination, positron emission tomography |
| الوصف: | Introduction The Addenbrooke’s Cognitive Examination III (ACE-III) is a brief test useful for neuropsychological assessment. Several studies have validated the test for the diagnosis of Alzheimer’s disease (AD) and frontotemporal dementia (FTD). In this study, we aimed to examine the metabolic correlates associated with the performance of ACE-III in AD and behavioral variant FTD. Methods We enrolled 300 participants in a cross-sectional study, including 180 patients with AD, 60 with behavioral FTD (bvFTD), and 60 controls. An 18 F-Fluorodeoxyglucose positron emission tomography study was performed in all cases. Correlation between the ACE-III and its domains (attention, memory, fluency, language, and visuospatial) with the brain metabolism was estimated. Results The ACE-III showed distinct neural correlates in bvFTD and AD, effectively capturing the most relevant regions involved in these disorders. Neural correlates differed for each domain, especially in the case of bvFTD. Lower ACE-III scores were associated with more advanced stages in both disorders. The ACE-III exhibited high discrimination between bvFTD vs. HC, and between AD vs. HC. Additionally, it was sensitive to detect hypometabolism in brain regions associated with bvFTD and AD. Conclusion Our study contributes to the knowledge of the brain regions associated with ACE-III, thereby facilitating its interpretation, and highlighting its suitability for screening and monitoring. This study provides further validation of ACE-III in the context of AD and FTD. |
| نوع الوثيقة: | still image |
| اللغة: | unknown |
| العلاقة: | https://figshare.com/articles/figure/Image_1_FDG-PET-based_neural_correlates_of_Addenbrooke_s_cognitive_examination_III_scores_in_Alzheimer_s_disease_and_frontotemporal_degeneration_JPEG/24571489Test |
| DOI: | 10.3389/fpsyg.2023.1273608.s001 |
| الإتاحة: | https://doi.org/10.3389/fpsyg.2023.1273608.s001Test https://figshare.com/articles/figure/Image_1_FDG-PET-based_neural_correlates_of_Addenbrooke_s_cognitive_examination_III_scores_in_Alzheimer_s_disease_and_frontotemporal_degeneration_JPEG/24571489Test |
| حقوق: | CC BY 4.0 |
| رقم الانضمام: | edsbas.90D73542 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3389/fpsyg.2023.1273608.s001 |
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