دورية أكاديمية
Titanium-Nitride-Oxide-Coated vs Everolimus-Eluting Stents in Acute Coronary Syndrome: 5-Year Clinical Outcomes of the TIDES-ACS Randomized Clinical Trial.
| العنوان: | Titanium-Nitride-Oxide-Coated vs Everolimus-Eluting Stents in Acute Coronary Syndrome: 5-Year Clinical Outcomes of the TIDES-ACS Randomized Clinical Trial. |
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| المؤلفون: | Bouisset, F., Sia, J., Mizukami, T., Karjalainen, P.P., Tonino, PAL, Pijls, NHJ, Van der Heyden, J., Romppanen, H., Kervinen, K., Airaksinen, JKE, Lalmand, J., Frambach, P., Roza da Costa, B., Collet, C., De Bruyne, B. |
| المساهمون: | TIDES-ACS Study Group |
| المصدر: | JAMA cardiology, vol. 8, no. 7, pp. 703-708 |
| سنة النشر: | 2023 |
| المجموعة: | Université de Lausanne (UNIL): Serval - Serveur académique lausannois |
| مصطلحات موضوعية: | Humans, Female, Middle Aged, Male, Everolimus/pharmacology, Everolimus/therapeutic use, Acute Coronary Syndrome/surgery, Acute Coronary Syndrome/drug therapy, Drug-Eluting Stents, Treatment Outcome, Percutaneous Coronary Intervention/adverse effects, Stents, Myocardial Infarction/epidemiology, Myocardial Infarction/etiology, Death |
| الوصف: | Titanium-nitride-oxide (TiNO)-coated stents show faster strut coverage compared with drug-eluting stents without excessive intimal-hyperplasia observed in bare metal stents. It is important to study long-term clinical outcomes after treatment of patients with an acute coronary syndrome (ACS) by TiNO-coated stents, which are neither drug-eluting stents nor bare metal stents. To compare the rate of main composite outcome of cardiac death, myocardial infarction (MI), or ischemia-driven target lesion revascularization at 5 years in patients with ACS randomized to receive either a TiNO-coated stent or a third-generation everolimus-eluting stent (EES). This multicenter, randomized, controlled, open-label trial was conducted in 12 clinical sites in 5 European countries and enrolled patients from January 2014 to August 2016. Patients presenting with ACS (ST-segment elevation MI, non-ST-segment elevation MI, and unstable angina) with at least 1 de novo lesion were randomized to receive either a TiNO-coated stent or an EES. The present report analyzes the long-term follow-up for the main composite outcome and its individual components. Analysis took place between November 2022 to March 2023. The primary end point was a composite of cardiac death, MI, or target lesion revascularization at 12-month follow-up. A total of 1491 patients with ACS were randomly assigned to receive either TiNO-coated stents (989 [66.3%]) or EES (502 [33.7%]). The mean (SD) age was 62.7 (10.8) years, and 363 (24.3%) were female. At 5 years, the main composite outcome events occurred in 111 patients (11.2%) in the TiNO group vs 60 patients (12%) in the EES group (hazard ratio [HR], 0.94; 95% CI, 0.69-1.28; P = .69). The rate of cardiac death was 0.9% (9 of 989) vs 3.0% (15 of 502) (HR, 0.30; 95% CI, 0.13-0.69; P = .005), the rate of MI was 4.6% (45 of 989) vs 7.0% (35 of 502) (HR, 0.64; 95% CI, 0.41-0.99; P = .049), the rate of stent thrombosis was 1.2% (12 of 989) vs 2.8% (14 of 502) (HR, 0.43; 95% CI, 0.20-0.93; P = .034), and the rate of target ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/37203243; info:eu-repo/semantics/altIdentifier/eissn/2380-6591; https://serval.unil.ch/notice/serval:BIB_530B9733F3A5Test |
| DOI: | 10.1001/jamacardio.2023.1373 |
| الإتاحة: | https://doi.org/10.1001/jamacardio.2023.1373Test https://serval.unil.ch/notice/serval:BIB_530B9733F3A5Test |
| رقم الانضمام: | edsbas.90BE9712 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1001/jamacardio.2023.1373 |
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