صورة
A Virtual Chromoendoscopy Artificial Intelligence System To Detect Endoscopic And Histologic Remission In Ulcerative Colitis
| العنوان: | A Virtual Chromoendoscopy Artificial Intelligence System To Detect Endoscopic And Histologic Remission In Ulcerative Colitis |
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| المؤلفون: | Iacucci M., Cannatelli, R., Parigi, T.L., Buda, A., Labarile, N., Nardone, O. M., Tontini, G. E., Rimondi, A., Bazarova, A., Bhandari, P., Bisschops, R., De Hertogh, G., Del Amor, R., Ferraz, J. G., Goetz, M., Gui, S. X., Hayee, B., Kiesslich, R., Lazarev, M., Naranjo, V., Panaccione, R., Parra-Blanco, A., Pastorelli, L., Rath, T., Røyset, E. S., Vieth, M., Villanacci, V., Zardo, D., Ghosh, S., Grisan, E. |
| سنة النشر: | 2022 |
| المجموعة: | LSBU Research Open (London South Bank University) |
| الوصف: | Background Endoscopic and histologic activity are important therapeutic targets in ulcerative colitis (UC). The Paddington International Virtual ChromoendoScopy ScOre (PICaSSO)1 demonstrated that enhanced visualization of subtle mucosal and vascular inflammatory changes correlated strongly with histology. However, without adequate training, the subjective evaluation of white light (WL) and VCE endoscopic scores varies between observers. We aimed to develop an artificial intelligence (AI) system for objective assessment of endoscopic disease activity and predict histology related to both white light and VCE videos. Methods 559 endoscopy videos (67280 frames) from 302 patients representative of all grades of inflammation, from our prospective PICaSSO multicentre study1 were used to develop a convolutional neural network (CNN). 316 videos were divided into training (254) and validation (62) sets. 243 additional videos (122 patients) were used as test cohort. The videos were edited to separate clips with WL and with VCE, and assessed using Ulcerative Colitis Endoscopic Index of Severity (UCEIS) and PICaSSO, respectively. The classification stage of a pre-trained ResNet50 CNN classifier was trained to predict the healing or active inflammation on video frames. One network was trained to predict endoscopic remission (ER) as UCEIS‰¤1 from WL frames, and a second network was trained to predict PICaSSO‰¤3 from VCE. Figure 1 Histological remission (HR) was defined as Robarts Histological Index (RHI) ‰¤3 with no neutrophils in lamina propria or epithelium. Results In the validation cohort, our system predicted ER (UCEIS ‰¤1) in WL videos with 82% sensitivity (Se), 94% specificity (Sp), and an area under the ROC curve (AUROC) of 0.92. For the detection of remission in VCE videos (PICaSSO ‰¤3) Se was 74%, Sp 95%, and AUROC 0.95. In the testing cohort of independent videos, the diagnostic performance for both cut offs of ER remained similar. Table 1 Our system also had an excellent diagnostic performance for the ... |
| نوع الوثيقة: | still image |
| وصف الملف: | application/vnd.openxmlformats-officedocument.wordprocessingml.document |
| اللغة: | unknown |
| العلاقة: | https://openresearch.lsbu.ac.uk/download/98c0d8ee91c4ae15592a22c234d1460c979f42ddff9a4d9643b86e25598e729b/15678/A%20VIRTUAL%20CHROMOENDOSCOPY%20ARTIFICIAL%20INTELLIGENCE%20SYSTEM%20TO%20DETECT%20ENDOSCOPIC%20AND%20HISTOLOGIC%20REMISSION%20IN%20ULCERATIVE%20COLITIS.docxTest; Iacucci M., Cannatelli, R., Parigi, T.L., Buda, A., Labarile, N., Nardone, O. M., Tontini, G. E., Rimondi, A., Bazarova, A., Bhandari, P., Bisschops, R., De Hertogh, G., Del Amor, R., Ferraz, J. G., Goetz, M., Gui, S. X., Hayee, B., Kiesslich, R., Lazarev, M., Naranjo, V., Panaccione, R., Parra-Blanco, A., Pastorelli, L., Rath, T., Røyset, E. S., Vieth, M., Villanacci, V., Zardo, D., Ghosh, S. and Grisan, E. (2022). A Virtual Chromoendoscopy Artificial Intelligence System To Detect Endoscopic And Histologic Remission In Ulcerative Colitis. Digestive Disease Week - DDW 2022. San Diego (CA) 21 - 24 May 2022 |
| الإتاحة: | https://openresearch.lsbu.ac.uk/item/90y9xTest https://openresearch.lsbu.ac.uk/download/98c0d8ee91c4ae15592a22c234d1460c979f42ddff9a4d9643b86e25598e729b/15678/A%20VIRTUAL%20CHROMOENDOSCOPY%20ARTIFICIAL%20INTELLIGENCE%20SYSTEM%20TO%20DETECT%20ENDOSCOPIC%20AND%20HISTOLOGIC%20REMISSION%20IN%20ULCERATIVE%20COLITIS.docxTest |
| حقوق: | CC BY 4.0 |
| رقم الانضمام: | edsbas.90A2536 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |