دورية أكاديمية
Notch1 switches progenitor competence in inducing medulloblastoma
| العنوان: | Notch1 switches progenitor competence in inducing medulloblastoma |
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| المؤلفون: | Ballabio C., Gianesello M., Lago C., Okonechnikov K., Anderle M., Aiello G., Antonica F., Zhang T., Gianno F., Giangaspero F., Hassan B. A., Pfister S. M., Tiberi L. |
| المساهمون: | Ballabio, C., Gianesello, M., Lago, C., Okonechnikov, K., Anderle, M., Aiello, G., Antonica, F., Zhang, T., Gianno, F., Giangaspero, F., Hassan, B. A., Pfister, S. M., Tiberi, L. |
| بيانات النشر: | American Association for the Advancement of Science Washington, DC 20005 Stati Uniti |
| سنة النشر: | 2021 |
| المجموعة: | Sapienza Università di Roma: CINECA IRIS |
| مصطلحات موضوعية: | notch 1, medulloblastoma, group 3 MB, brain cancer, cancer subtypes |
| الوصف: | The identity of the cell of origin is a key determinant of cancer subtype, progression, and prognosis. Group 3 medulloblastoma (MB) is a malignant childhood brain cancer with poor prognosis and few candidates as putative cell of origin. We overexpressed the group 3 MB genetic drivers MYC and Gfi1 in different candidate cells of origin in the postnatal mouse cerebellum. We found that S100b+ cells are competent to initiate group 3 MB, and we observed that S100b+ cells have higher levels of Notch1 pathway activity compared to Math1+ cells. We found that additional activation of Notch1 in Math1+ and Sox2+ cells was sufficient to induce group 3 MB upon MYC/Gfi1 expression. Together, our data suggest that the Notch1 pathway plays a critical role in group 3 MB initiation. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/34162555; info:eu-repo/semantics/altIdentifier/wos/WOS:000664978800013; volume:7; issue:26; numberofpages:14; journal:SCIENCE ADVANCES; https://hdl.handle.net/11573/1676445Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85108698286 |
| DOI: | 10.1126/sciadv.abd2781 |
| الإتاحة: | https://doi.org/10.1126/sciadv.abd2781Test https://hdl.handle.net/11573/1676445Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.90913AA6 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1126/sciadv.abd2781 |
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