دورية أكاديمية
An Odorant-Binding Protein Required for Suppression of Sweet Taste by Bitter Chemicals
| العنوان: | An Odorant-Binding Protein Required for Suppression of Sweet Taste by Bitter Chemicals |
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| المساهمون: | Yong Taek Jeong, Jaewon Shim, So Ra Oh, Hong In Yoon, Chul Hoon Kim, Seok Jun Moon, Craig Montell, Jeong, Yong Taek, Kim, Chul Hoon, Moon, Seok Jun, Shim, Jae Won, Oh, So Ra, Yoon, Hong In |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | Action Potentials/drug effects, Action Potentials/physiology, Analgesics, Non-Narcotic/pharmacology, Animals, Genetically Modified, Choice Behavior/drug effects, Choice Behavior/physiology, Dose-Response Relationship, Drug, Drosophila Proteins/genetics, Drosophila Proteins/metabolism, Drosophila melanogaster, Electrodes, Food Preferences/drug effects, Food Preferences/physiology, Green Fluorescent Proteins/genetics, Green Fluorescent Proteins/metabolism, Mutation/genetics, Odorants, Quaternary Ammonium Compounds/pharmacology, Quinine/pharmacology, Receptors, Odorant/genetics, Odorant/metabolism, Sensilla/drug effects, Sensilla/physiology, Sucrose/administration & dosage, Sweetening Agents/pharmacology, Taste/drug effects |
| الوصف: | Animals often must decide whether or not to consume a diet that contains competing attractive and aversive compounds. Here, using the fruit fly, Drosophila melanogaster, we describe a mechanism that influences this decision. Addition of bitter compounds to sucrose suppressed feeding behavior, and this inhibition depended on an odorant-binding protein (OBP) termed OBP49a. In wild-type flies, bitter compounds suppressed sucrose-induced action potentials, and the inhibition was impaired in Obp49a mutants. However, loss of OBP49a did not affect action potentials in sugar- or bitter-activated gustatory receptor neurons (GRNs) when the GRNs were presented with just one type of tastant. OBP49a was expressed in accessory cells and acted non-cell-autonomously to attenuate nerve firings in sugar-activated GRNs when bitter compounds were combined with sucrose. These findings demonstrate an unexpected role for an OBP in taste and identify a molecular player involved in the integration of opposing attractive and aversive gustatory inputs. ; open |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| تدمد: | 0896-6273 1097-4199 |
| العلاقة: | NEURON; J02345; OAK-2013-01230; https://ir.ymlib.yonsei.ac.kr/handle/22282913/87347Test; http://www.sciencedirect.com/science/article/pii/S0896627313005412Test; T201302416; NEURON, Vol.79(4) : 725-737, 2013 |
| DOI: | 10.1016/j.neuron.2013.06.025 |
| الإتاحة: | https://doi.org/10.1016/j.neuron.2013.06.025Test https://ir.ymlib.yonsei.ac.kr/handle/22282913/87347Test http://www.sciencedirect.com/science/article/pii/S0896627313005412Test |
| حقوق: | CC BY-NC-ND 2.0 KR ; https://creativecommons.org/licenses/by-nc-nd/2.0/krTest/ ; not free |
| رقم الانضمام: | edsbas.906085FD |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 08966273 10974199 |
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| DOI: | 10.1016/j.neuron.2013.06.025 |