التفاصيل البيبلوغرافية
| العنوان: |
Pharmacological Blockade of the Chemokine Receptor CCR1 Protects Mice from Systemic Candidiasis of Hematogenous Origin |
| المؤلفون: |
Lionakis, Michail S., Albert, Nathaniel D., Swamydas, Muthulekha, Lee, Chyi-Chia R., Loetscher, Pius, Kontoyiannis, Dimitrios P. |
| المساهمون: |
Division of Intramural Research, National Institute of Allergy and Infectious Diseases |
| المصدر: |
Antimicrobial Agents and Chemotherapy ; volume 61, issue 3 ; ISSN 0066-4804 1098-6596 |
| بيانات النشر: |
American Society for Microbiology |
| سنة النشر: |
2017 |
| الوصف: |
Systemic candidiasis is a leading cause of nosocomial bloodstream infection with a high mortality rate despite treatment. Immune-based strategies are needed to improve outcomes. We previously reported that genetic deficiency in the chemokine receptor CCR1 improves survival and ameliorates tissue damage in Candida -infected mice. Here, we found that treatment of immunocompetent Candida -infected mice with the CCR1-selective antagonist BL5923 improves survival, decreases the kidney fungal burden, and protects from renal tissue injury. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.1128/aac.02365-16 |
| DOI: |
10.1128/AAC.02365-16 |
| الإتاحة: |
https://doi.org/10.1128/aac.02365-16Test |
| حقوق: |
https://journals.asm.org/non-commercial-tdm-licenseTest |
| رقم الانضمام: |
edsbas.9054D501 |
| قاعدة البيانات: |
BASE |
