دورية أكاديمية
NK-like CD8
| العنوان: | NK-like CD8 |
|---|---|
| المؤلفون: | Roy Chowdhury, Roshni, Valainis, John R, Dubey, Megha, von Boehmer, Lotta, Sola, Elsa, Wilhelmy, Julie, Guo, Jing, Kask, Oliver, Ohanyan, Mane, Sun, Meng, Huang, Huang, Huang, Xianxi, Nguyen, Patricia K, Scriba, Thomas J, Davis, Mark M, Bendall, Sean C, Chien, Yueh-Hsiu |
| المصدر: | Sci Immunol ; ISSN:2470-9468 ; Volume:8 ; Issue:81 |
| بيانات النشر: | Atypon |
| سنة النشر: | 2023 |
| المجموعة: | PubMed Central (PMC) |
| الوصف: | The response of gamma delta (γδ) T cells in the acute versus chronic phases of the same infection is unclear. How γδ T cells function in acute Mycobacterium tuberculosis (Mtb) infection is well characterized, but their response during persistent Mtb infection is not well understood, even though most infections with Mtb manifest as a chronic, clinically asymptomatic state. Here, we analyze peripheral blood γδ T cells from a South African adolescent cohort and show that a unique CD8+ γδ T cell subset with features of "memory inflation" expands in chronic Mtb infection. These cells are hyporesponsive to T cell receptor (TCR)-mediated signaling but, like NK cells, can mount robust CD16-mediated cytotoxic responses. These CD8+ γδ T cells comprise a highly focused TCR repertoire, with clonotypes that are Mycobacterium specific but not phosphoantigen reactive. Using multiparametric single-cell pseudo-time trajectory analysis, we identified the differentiation paths that these CD8+ γδ T cells follow to develop into effectors in this infection state. Last, we found that circulating CD8+ γδ T cells also expand in other chronic inflammatory conditions, including cardiovascular disease and cancer, suggesting that persistent antigenic exposure may drive similar γδ T cell effector programs and differentiation fates. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://doi.org/10.1126/sciimmunol.ade3525Test; https://pubmed.ncbi.nlm.nih.gov/37000856Test; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10408713Test/ |
| DOI: | 10.1126/sciimmunol.ade3525 |
| الإتاحة: | https://doi.org/10.1126/sciimmunol.ade3525Test https://pubmed.ncbi.nlm.nih.gov/37000856Test https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10408713Test/ |
| رقم الانضمام: | edsbas.903E54A1 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1126/sciimmunol.ade3525 |
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