التفاصيل البيبلوغرافية
| العنوان: |
An in-silico analysis of electrically evoked responses of midget and parasol retinal ganglion cells in different retinal regions |
| المؤلفون: |
Song, Xiaoyu, Qiu, Shirong, Shivdasani, Mohit N, Zhou, Feng, Liu, Zhengyang, Ma, Saidong, Chai, Xinyu, Chen, Yao, Cai, Xuan, Guo, Tianruo, Li, Liming |
| المساهمون: |
National Natural Science Foundation of China |
| المصدر: |
Journal of Neural Engineering ; volume 19, issue 2, page 026018 ; ISSN 1741-2560 1741-2552 |
| بيانات النشر: |
IOP Publishing |
| سنة النشر: |
2022 |
| الوصف: |
Objective . Visual outcomes provided by present retinal prostheses that primarily target retinal ganglion cells (RGCs) through epiretinal stimulation remain rudimentary, partly due to the limited knowledge of retinal responses under electrical stimulation. Better understanding of how different retinal regions can be quantitatively controlled with high spatial accuracy, will be beneficial to the design of micro-electrode arrays and stimulation strategies for next-generation wide-view, high-resolution epiretinal implants. Approach . A computational model was developed to assess neural activity at different eccentricities (2 mm and 5 mm) within the human retina. This model included midget and parasol RGCs with anatomically accurate cell distribution and cell-specific morphological information. We then performed in silico investigations of region-specific RGC responses to epiretinal electrical stimulation using varied electrode sizes (5–210 µ m diameter), emulating both commercialized retinal implants and recently developed prototype devices. Main results . Our model of epiretinal stimulation predicted RGC population excitation analogous to the complex percepts reported in human subjects. Following this, our simulations suggest that midget and parasol RGCs have characteristic regional differences in excitation under preferred electrode sizes. Relatively central (2 mm) regions demonstrated higher number of excited RGCs but lower overall activated receptive field (RF) areas under the same stimulus amplitudes (two-way analysis of variance (ANOVA), p < 0.05). Furthermore, the activated RGC numbers per unit active RF area (number-RF ratio) were significantly higher in central than in peripheral regions, and higher in the midget than in the parasol population under all tested electrode sizes (two-way ANOVA, p < 0.05). Our simulations also suggested that smaller electrodes exhibit a higher range of controllable stimulation parameters to achieve pre-defined performance of RGC excitation. An empirical model: I ... |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
unknown |
| DOI: |
10.1088/1741-2552/ac5b18 |
| DOI: |
10.1088/1741-2552/ac5b18/pdf |
| الإتاحة: |
https://doi.org/10.1088/1741-2552/ac5b18Test |
| حقوق: |
https://iopscience.iop.org/page/copyrightTest ; https://iopscience.iop.org/info/page/text-and-data-miningTest |
| رقم الانضمام: |
edsbas.901CF9C |
| قاعدة البيانات: |
BASE |
