دورية أكاديمية
The different natural estrogens promote endothelial healing through distinct cell targets
| العنوان: | The different natural estrogens promote endothelial healing through distinct cell targets |
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| المؤلفون: | Davezac, Morgane, Zahreddine, Rana, Buscato, Melissa, Smirnova, Natalia F., Febrissy, Chanaëlle, Laurell, Henrik, Gilardi-Bresson, Silveric, Adlanmerini, Marine, Liere, Philippe, Flouriot, Gilles, Guennoun, Rachida, Laffargue, Muriel, Foidart, Jean‐michel, Lenfant, Françoise, Arnal, J.-F., Métivier, Raphaël, Fontaine, Coralie |
| المساهمون: | Institut des Maladies Métaboliques et Casdiovasculaires (UPS/Inserm U1297 - I2MC), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM), Maladies et hormones du système nerveux (DHNS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique EHESP (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), VIB-KU Leuven Center for Microbiology Leuven, Belgium, Catholic University of Leuven = Katholieke Universiteit Leuven (KU Leuven), Institut de Génétique et Développement de Rennes (IGDR), Université de Rennes (UR)-Centre National de la Recherche Scientifique (CNRS)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ) |
| المصدر: | ISSN: 2379-3708 ; JCI Insight ; https://hal.science/hal-04040711Test ; JCI Insight, 2023, 8 (5), ⟨10.1172/jci.insight.161284⟩. |
| بيانات النشر: | HAL CCSD American Society for Clinical Investigation |
| سنة النشر: | 2023 |
| المجموعة: | Archive ouverte HAL (Hyper Article en Ligne, CCSD - Centre pour la Communication Scientifique Directe) |
| مصطلحات موضوعية: | Endocrinology, Endothelial cells, Sex hormones, Vascular Biology, Cardiovascular disease, [SDV.MHEP.EM]Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism, [SDV.BC]Life Sciences [q-bio]/Cellular Biology |
| الوصف: | International audience ; The main estrogen, 17β-estradiol (E2), exerts several beneficial vascular actions through estrogen receptor α (ERα) in endothelial cells. However, the impact of other natural estrogens such as estriol (E3) and estetrol (E4) on arteries remains poorly described. In the present study, we report the effects of E3 and E4 on endothelial healing after carotid artery injuries in vivo. After endovascular injury, which preserves smooth muscle cells (SMCs), E2, E3, and E4 equally stimulated reendothelialization. By contrast, only E2 and E3 accelerated endothelial healing after perivascular injury that destroys both endothelial cells and SMCs, suggesting an important role of this latter cell type in E4’s action, which was confirmed using Cre/lox mice inactivating ERα in SMCs. In addition, E4 mediated its effects independently of ERα membrane-initiated signaling, in contrast with E2. Consistently, RNA sequencing analysis revealed that transcriptomic and cellular signatures in response to E4 profoundly differed from those of E2. Thus, whereas acceleration of endothelial healing by estrogens had been viewed as entirely dependent on endothelial ERα, these results highlight the very specific pharmacological profile of the natural estrogen E4, revealing the importance of dialogue between SMCs and endothelial cells in its arterial protection. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/36729672; hal-04040711; https://hal.science/hal-04040711Test; https://hal.science/hal-04040711/documentTest; https://hal.science/hal-04040711/file/pdfTest; PUBMED: 36729672 |
| DOI: | 10.1172/jci.insight.161284 |
| الإتاحة: | https://doi.org/10.1172/jci.insight.161284Test https://hal.science/hal-04040711Test https://hal.science/hal-04040711/documentTest https://hal.science/hal-04040711/file/pdfTest |
| حقوق: | http://creativecommons.org/licenses/byTest/ ; info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.8FD1A78C |
| قاعدة البيانات: | BASE |
| DOI: | 10.1172/jci.insight.161284 |
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