دورية أكاديمية
TMEM106B and CPOX are genetic determinants of cerebrospinal fluid Alzheimer's disease biomarker levels
| العنوان: | TMEM106B and CPOX are genetic determinants of cerebrospinal fluid Alzheimer's disease biomarker levels |
|---|---|
| المؤلفون: | Hong, Shengjun, Dobricic, Valerija, Ohlei, Olena, Bos, Isabelle, Vos, Stephanie J B, Prokopenko, Dmitry, Tijms, Betty M, Andreasson, Ulf, Blennow, Kaj, Vandenberghe, Rik, Gabel, Silvy, Scheltens, Philip, Teunissen, Charlotte E, Engelborghs, Sebastiaan, Frisoni, Giovanni, Blin, Olivier, Richardson, Jill C, Bordet, Regis, Lleó, Alberto, Alcolea, Daniel, Popp, Julius, Clark, Christopher, Peyratout, Gwendoline, Martinez-Lage, Pablo, Tainta, Mikel, Dobson, Richard J B, Legido-Quigley, Cristina, Sleegers, Kristel, Van Broeckhoven, Christine, Tanzi, Rudolph E, Ten Kate, Mara, Wittig, Michael, Franke, Andre, Lill, Christina M, Barkhof, Frederik, Lovestone, Simon, Streffer, Johannes, Zetterberg, Henrik, Visser, Pieter Jelle, Bertram, Lars, Alzheimer's Disease Neuroimaging Initiative (ADNI) |
| المصدر: | ISSN: 1552-5260 ; Alzheimer's & dementia, vol. 17, no. 10 (2021) p. 1628-1640. |
| سنة النشر: | 2021 |
| المجموعة: | Université de Genève: Archive ouverte UNIGE |
| مصطلحات موضوعية: | info:eu-repo/classification/ddc/618.97, Alzheimer's disease, Biomarker, Cerebrospinal fluid, Chitinase-3-like protein 1, Genome-wide association study, Neurofilament light, Neurogranin, Aged, Alzheimer Disease / genetics, Biomarkers / cerebrospinal fluid, Chitinase-3-Like Protein 1 / genetics, Female, Humans, Male, Membrane Proteins / genetics, Nerve Tissue Proteins / genetics, Neurofilament Proteins / genetics, Neurogranin / cerebrospinal fluid |
| الوصف: | Introduction: Neurofilament light (NfL), chitinase-3-like protein 1 (YKL-40), and neurogranin (Ng) are biomarkers for Alzheimer's disease (AD) to monitor axonal damage, astroglial activation, and synaptic degeneration, respectively. Methods: We performed genome-wide association studies (GWAS) using DNA and cerebrospinal fluid (CSF) samples from the EMIF-AD Multimodal Biomarker Discovery study for discovery, and the Alzheimer's Disease Neuroimaging Initiative study for validation analyses. GWAS were performed for all three CSF biomarkers using linear regression models adjusting for relevant covariates. Results: We identify novel genome-wide significant associations between DNA variants in TMEM106B and CSF levels of NfL, and between CPOX and YKL-40. We confirm previous work suggesting that YKL-40 levels are associated with DNA variants in CHI3L1. Discussion: Our study provides important new insights into the genetic architecture underlying interindividual variation in three AD-related CSF biomarkers. In particular, our data shed light on the sequence of events regarding the initiation and progression of neuropathological processes relevant in AD. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/33991015; info:eu-repo/grantAgreement/EC/FP7/115372/EU/European Medical Information Framework/EMIF; https://archive-ouverte.unige.ch/unige:171474Test; unige:171474 |
| الإتاحة: | https://doi.org/10.1002/alz.12330Test https://archive-ouverte.unige.ch/unige:171474Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.8F9964EE |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |