دورية أكاديمية
Incoming HIV virion-derived Gag Spacer Peptide 2 (p1) is a target of effective CD8+ T cell antiviral responses
| العنوان: | Incoming HIV virion-derived Gag Spacer Peptide 2 (p1) is a target of effective CD8+ T cell antiviral responses |
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| المؤلفون: | Yang, H, Llano, A, Cedeño, S, von Delft, A, Corcuera, A, Gillespie, GM, Knox, A, Leneghan, DB, Frater, J, Stöhr, W, Fidler, S, Mothe, B, Mak, J, Brander, C, Ternette, N, Dorrell, L |
| المساهمون: | group, Research in Viral Eradication of Reservoirs (RIVER) trial study |
| بيانات النشر: | Cell Press |
| سنة النشر: | 2023 |
| المجموعة: | Oxford University Research Archive (ORA) |
| الوصف: | Persistence of HIV through integration into host DNA in CD4+ T cells presents a major barrier to virus eradication. Viral integration may be curtailed when CD8+ T cells are triggered to kill infected CD4+ T cells through recognition of histocompatibility leukocyte antigen (HLA) class I-bound peptides derived from incoming virions. However, this has been reported only in individuals with “beneficial” HLA alleles that are associated with superior HIV control. Through interrogation of the pre-integration immunopeptidome, we obtain proof of early presentation of a virion-derived HLA-A∗02:01-restricted epitope, FLGKIWPSH (FH9), located in Gag Spacer Peptide 2 (SP2). FH9-specific CD8+ T cell responses are detectable in individuals with primary HIV infection and eliminate HIV-infected CD4+ T cells prior to virus production in vitro. Our data show that non-beneficial HLA class I alleles can elicit an effective antiviral response through early presentation of HIV virion-derived epitopes and also demonstrate the importance of SP2 as an immune target. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://ora.ox.ac.uk/objects/uuid:17a49526-2c1e-41c6-b3ec-08e777651760Test; https://doi.org/10.1016/j.celrep.2021.109103Test |
| DOI: | 10.1016/j.celrep.2021.109103 |
| الإتاحة: | https://doi.org/10.1016/j.celrep.2021.109103Test https://ora.ox.ac.uk/objects/uuid:17a49526-2c1e-41c6-b3ec-08e777651760Test |
| حقوق: | info:eu-repo/semantics/openAccess ; CC Attribution (CC BY) |
| رقم الانضمام: | edsbas.8F933AF6 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.celrep.2021.109103 |
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