دورية أكاديمية
Gastrointestinal manifestations in mastocytosis: A study of 83 patients.
| العنوان: | Gastrointestinal manifestations in mastocytosis: A study of 83 patients. |
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| المؤلفون: | Sokol, Harry, Georgin-Lavialle, Sophie, Canioni, Danielle, Barete, Stéphane, Damaj, Gandhi, Soucie, Erinn, Bruneau, Julie, Chandesris, Marie-Olivia, Suarez, Felipe, Launay, Jean-Marie, Aouba, Achille, Grandpeix-Guyodo, Catherine, Lanternier, Fanny, Grosbois, Bernard, de Gennes, Christian, Cathébras, Pascal, Fain, Olivier, Hoyeau-Idrissi, Nadia, Dubreuil, Patrice, Lortholary, Olivier, Beaugerie, Laurent, Ranque, Brigitte, Hermine, Olivier |
| المساهمون: | Université Pierre et Marie Curie - Paris 6 (UPMC), CHU Saint-Antoine AP-HP, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Cytokines, hématopoïèse et réponse immune (CHRI), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Hôpital Necker - Enfants Malades AP-HP, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), CHU Tenon AP-HP, CHU Amiens-Picardie, Centre d'Immunologie de Marseille - Luminy (CIML), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Laboratory of molecular mechanisms of hematologic disorders and therapeutic implications (ERL 8254 - Equipe Inserm U1163), Imagine - Institut des maladies génétiques (IMAGINE - U1163), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre de Référence Déficits Immunitaires Héréditaires (CEREDIH), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Necker - Enfants Malades AP-HP, Génétique Humaine des Maladies Infectieuses (Inserm U980), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service Biochimie et Biologie Moleculaire, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Lariboisière-Fernand-Widal APHP, Centre d'infectiologie Necker-Pasteur CHU Necker, Institut Pasteur Paris (IP)-Hôpital Necker - Enfants Malades AP-HP, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service de Médecine interne et immunologie clinique Rennes = internal medicine and clinical immunology Rennes, Centre Hospitalier Universitaire de Rennes CHU Rennes = Rennes University Hospital Ponchaillou, service de médecine interne, Université Paris 13 (UP13)-Hôpital Jean Verdier AP-HP, Centre de Recherche en Cancérologie de Marseille (CRCM), Aix Marseille Université (AMU)-Institut Paoli-Calmettes (IPC), Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), AB Science, AB Science Headquarter, Département de Pédiatrie et maladies infectieuses CHU Necker, Equipe mobile d'infectiologie, Université Paris Descartes - Paris 5 (UPD5), Association Franc, aise pour les Initiatives et la Recherche sur le Mastocyte et les Mastocytoses (AFIRMM), Canceropole de l'ile de France, CNRS-AP-HP, INSERM, la Ligue Nationale Contre le Cancer equipe labellisee, INCA, Ligue contre le cancer et INCA |
| المصدر: | ISSN: 0091-6749 ; Journal of Allergy and Clinical Immunology ; https://hal.science/hal-00849794Test ; Journal of Allergy and Clinical Immunology, 2013, 132 (4), pp.866-873.e3. ⟨10.1016/j.jaci.2013.05.026⟩. |
| بيانات النشر: | HAL CCSD Elsevier |
| سنة النشر: | 2013 |
| المجموعة: | Université de Rennes 1: Publications scientifiques (HAL) |
| مصطلحات موضوعية: | Mastocytosis, c-Kit, MAST-CELL DISEASE, KIT MUTATION, DISORDERS, ABNORMALITIES, INVOLVEMENT, ACTIVATION, TRYPTASE, mast cells, gastrointestinal tract, SYSTEMIC MASTOCYTOSIS, LEUKEMIA, MALABSORPTION, [CHIM.ORGA]Chemical Sciences/Organic chemistry |
| الوصف: | International audience ; BACKGROUND: Mastocytosis is a heterogeneous disease characterized by mast cell accumulation in 1 or more organs. Gastrointestinal manifestations of systemic mastocytosis have been previously studied in small cohorts of patients, and no specific histologic description is available. OBJECTIVE: We sought to assess the clinical and pathologic features of gastrointestinal manifestations in patients with mastocytosis. METHODS: Medical history and gastrointestinal symptoms of patients with mastocytosis (n = 83) were compared with those of matched healthy subjects (n = 83) by means of patient questionnaire. Data were analyzed for epidemiologic, clinical, biological, and genetic factors associated with gastrointestinal symptoms for patients with mastocytosis. A comparative analysis of gastrointestinal histology from patients with mastocytosis (n = 23), control subjects with inflammatory bowel disease (n = 17), and healthy subjects (n = 19) was performed. RESULTS: The following gastrointestinal symptoms occurred more frequently and were more severe in patients with mastocytosis than in healthy subjects: bloating (33% vs 7.2%, P < .0001), abdominal pain (27.3% vs 4.8%, P < .0001), nausea (23% vs 8.4%, P = .02), and diarrhea (33.85% vs 1.2%, P < .0001). Patients with mastocytosis had a significantly higher incidence of personal history of duodenal ulcer (P = .02). Wild-type (WT) c-Kit was associated with diarrhea (P = .03). Specific histologic lesions were present in patients with mastocytosis but were not correlated with clinical symptoms. CONCLUSION: Gastrointestinal manifestations in patients with mastocytosis are highly prevalent and often severe. Clinical symptoms do not correspond to histologic findings, are nonspecific, and can simulate irritable bowel syndrome. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/23890756; hal-00849794; https://hal.science/hal-00849794Test; PRODINRA: 219412; PUBMED: 23890756; WOS: 000325096500013 |
| DOI: | 10.1016/j.jaci.2013.05.026 |
| الإتاحة: | https://doi.org/10.1016/j.jaci.2013.05.026Test https://hal.science/hal-00849794Test |
| رقم الانضمام: | edsbas.8F2CE23B |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.jaci.2013.05.026 |
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