دورية أكاديمية
Brentuximab vedotin-containing escalated BEACOPP variants for newly diagnosed advanced-stage classical Hodgkin lymphoma: follow-up analysis of a randomized phase II study from the German Hodgkin Study Group
| العنوان: | Brentuximab vedotin-containing escalated BEACOPP variants for newly diagnosed advanced-stage classical Hodgkin lymphoma: follow-up analysis of a randomized phase II study from the German Hodgkin Study Group |
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| المؤلفون: | Damaschin, Carla, Goergen, Helen, Kreissl, Stefanie, Plütschow, Annette, Breywisch, Frank, Mathas, Stephan, Meissner, Julia, Sökler, Martin, Topp, Max S., Vucinic, Vladan, Zimmermann, Andreas, von Tresckow, Bastian, Fuchs, Michael, Engert, Andreas, Borchmann, Peter, Eichenauer, Dennis A. |
| المصدر: | http://lobid.org/resources/99370672770606441Test#!, 36(2):580-582. |
| سنة النشر: | 2021 |
| المجموعة: | Publisso (ZB MED-Publikationsportal Lebenswissenschaften) |
| مصطلحات موضوعية: | Letter, Lymphoma, Clinical Trials, Phase II as Topic/statistics, Neoplasm Recurrence, Local/pathology [MeSH], Neoplasms, Second Primary/pathology [MeSH], Cyclophosphamide/administration, Etoposide/administration, Male [MeSH], Randomized Controlled Trials as Topic/statistics, Bleomycin/administration, Combination drug therapy, Vincristine/administration, Hodgkin Disease/pathology [MeSH], Adolescent [MeSH], Female [MeSH], Follow-Up Studies [MeSH], Hodgkin Disease/drug therapy [MeSH], Second Primary/drug therapy [MeSH], Adult [MeSH], Humans [MeSH], Middle Aged [MeSH], Antineoplastic Combined Chemotherapy Protocols/therapeutic use [MeSH], Survival Rate [MeSH], Prognosis [MeSH], Young Adult [MeSH], Brentuximab Vedotin/administration, Local/drug therapy [MeSH] |
| الوصف: | Schizophrenia is a chronic and severe mental disorder that affects over 20 million people worldwide. Common symptoms include distortions in thinking, perception, emotions, language, and self awareness. Different hypotheses have been proposed to explain the development of schizophrenia, however, there are no unifying features between the proposed hypotheses. Schizophrenic patients have perturbed levels of glucose in their cerebrospinal fluid, indicating a disturbance in glucose metabolism. We have explored the possibility that disturbances in glucose metabolism can be a general mechanism for predisposition and manifestation of the disease. We discuss glucose metabolism as a network of signaling pathways. Glucose and glucose metabolites can have diverse actions as signaling molecules, such as regulation of transcription factors, hormone and cytokine secretion and activation of neuronal cells, such as microglia. The presented model challenges well-established concepts in enzyme kinetics and glucose metabolism. We have developed a 'two-cell' model of glucose metabolism, which can explain the effects of electroconvulsive therapy and the beneficial and side effects of olanzapine treatment. Arrangement of glycolytic enzymes into metabolic signaling complexes within the 'two hit' hypothesis, allows schizophrenia to be formulated in two steps. The 'first hit' is the dysregulation of the glucose signaling pathway. This dysregulation of glucose metabolism primes the central nervous system for a pathological response to a 'second hit' via the astrocytic glycogenolysis signaling pathway. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://repository.publisso.de/resource/frl:6443794Test; https://doi.org/10.1038/s41375-021-01386-zTest; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8807388Test/ |
| DOI: | 10.1038/s41375-021-01386-z |
| الإتاحة: | https://doi.org/10.1038/s41375-021-01386-zTest https://repository.publisso.de/resource/frl:6443794Test https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8807388Test/ |
| حقوق: | https://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: | edsbas.8F14851A |
| قاعدة البيانات: | BASE |
| DOI: | 10.1038/s41375-021-01386-z |
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