دورية أكاديمية
The effects of intestinal ischemia on the levels of serum immunoglobulin A in rats
| العنوان: | The effects of intestinal ischemia on the levels of serum immunoglobulin A in rats |
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| المؤلفون: | Demir, Süleyman, Yılmaz, Mustafa, Herek, Özkan, Akbulut, Metin |
| سنة النشر: | 2003 |
| المجموعة: | Pamukkale University Repository / Pamukkale Üniversitesi Açık Erişim Arşivi |
| مصطلحات موضوعية: | Diagnosis, Alkaline phosphatase, IgA, Immunoglobulin A, Intestinal ischemia, Lactate dehydrogenase, animal model, animal tissue, article, controlled study, immune response, intestine ischemia, male, nonhuman, priority journal, rat, Animals, Intestines, Ischemia, L-Lactate Dehydrogenase, Models, Animal, Rats |
| الوصف: | Many biochemical markers have been investigated in intestinal ischemia. However, the effects of intestinal ischemia on the level of serum immunoglobulin A (IgA) has apparently not been investigated in the literature, although the gastrointestinal system is one of the main sources of serum IgA. The aim of our study was to evaluate the changes of serum IgA levels during intestinal ischemia of varying duration in rats. Group 1 (n = 5) was created for control purposes, including the detection of the baseline values and the effects of the anesthetic agents. Group 2 (n = 20) rats underwent sham laparotomy. Group 3 (n = 20) had 50% of small intestine ischemia by the strangulated obstruction model. Serum samples were obtained by cardiac puncture 1 h after anesthetic agents were given in group 1. On the other hand, serum and intestine samples were obtained at 1 (T1, n= 5), 2 (T2, n= 5), 4 (T4, n=5) and 6 (T6, n= 5) h after the operation in groups 2 and 3. The levels of serum IgA, lactic dehydrogenase (LDH) and alkaline phosphatase (ALP) were determined. Pathologic specimens were graded in a masked manner. IgA levels were abruptly decreased to 8.49 ± 1.58 mg/dl in rats with intestinal ischemia at 1 h after the operation. This decrease in serum IgA at T1 in group 3 was statistically significant compared with the control and sham-operated groups (18.80 ± 1.15 mg/dl, 22.07 ± 1.54 mg/dl, respectively; P0.01). On the other hand, IgA levels were significantly elevated at T2 in the sham-operated group compared with control and intestinal ischemia groups (26.99 ± 2.96 mg/dl, 18.80 ± 1.15 mg/dl, 14.354 ± 2.62 mg/dl, respectively; P 0.05). The serum IgA levels decreased to above baseline values at T6 in group 2 (19.60 ± 2.78 mg/dl), while they increased to below baseline values in group 3 (17.60 ± 1.28 mg/dl). In group 3, IgA levels were elevated to baseline values, while a significant ischemia occurred at 4 and 6 h after operation. These results suggested that serum IgA is affected earlier by intestinal ischemia and ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| ردمك: | 978-0-00-186494-8 0-00-186494-7 |
| تدمد: | 0179-0358 |
| العلاقة: | Pediatric Surgery International; Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı; https://hdl.handle.net/11499/5215Test; https://doi.org/10.1007/s00383-003-1051-0Test; 19; 601; 604; 2-s2.0-0242389631; WOS:000186494700009 |
| DOI: | 10.1007/s00383-003-1051-0 |
| الإتاحة: | https://doi.org/10.1007/s00383-003-1051-0Test https://hdl.handle.net/11499/5215Test |
| حقوق: | none |
| رقم الانضمام: | edsbas.8EA25924 |
| قاعدة البيانات: | BASE |
| ردمك: | 9780001864948 0001864947 |
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| تدمد: | 01790358 |
| DOI: | 10.1007/s00383-003-1051-0 |