دورية أكاديمية
Murine models of B-cell lymphomas: promising tools for designing cancer therapies
| العنوان: | Murine models of B-cell lymphomas: promising tools for designing cancer therapies |
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| المؤلفون: | Donnou, S., Galand, C., Touitou, V., Sautes-Fridman, C., Fabry, Z., Fisson, S. |
| المساهمون: | Laboratoire Parisien de Psychologie Sociale (LAPPS), Université Paris 8 Vincennes-Saint-Denis (UP8)-Université Paris Nanterre (UPN), Immunologie moléculaire et biothérapies innovantes (IMBI), École Pratique des Hautes Études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université d'Évry-Val-d'Essonne (UEVE)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Généthon |
| المصدر: | Adv Hematol ; https://hal.science/hal-02881156Test ; Adv Hematol, 2012, 2012, pp.701704. ⟨10.1155/2012/701704⟩ |
| بيانات النشر: | HAL CCSD |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | [SDV]Life Sciences [q-bio] |
| الوصف: | International audience ; Human B-cell lymphomas, the fourth most common hematologic malignancy, are currently the subject of extensive research. The limited accessibility of biopsies, the heterogeneity among patients, and the subtypes of lymphomas have necessitated the development of animal models to decipher immune escape mechanisms and design new therapies. Here, we summarize the cell lines and murine models used to study lymphomagenesis, the lymphoma microenvironment, and the efficacy of new therapies. These data allow us to understand the role of the immune system in the fight against tumors. Exploring the advantages and limitations of immunocompetent versus immunodeficient models improves our understanding of the molecular and cellular mechanisms of tumor genesis and development as well as the fundamental processes governing the interaction of tumors and their host tissues. We posit that these basic preclinical investigations will open up new and promising approaches to designing better therapies. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/22400032; hal-02881156; https://hal.science/hal-02881156Test; PUBMED: 22400032; PUBMEDCENTRAL: PMC3287022 |
| DOI: | 10.1155/2012/701704 |
| الإتاحة: | https://doi.org/10.1155/2012/701704Test https://hal.science/hal-02881156Test |
| رقم الانضمام: | edsbas.8E66118E |
| قاعدة البيانات: | BASE |
| DOI: | 10.1155/2012/701704 |
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