دورية أكاديمية
Profiling of Canonical and Non-Traditional Cytokine Levels in Interferon-β-Treated Relapsing-Remitting-Multiple Sclerosis Patients
| العنوان: | Profiling of Canonical and Non-Traditional Cytokine Levels in Interferon-β-Treated Relapsing-Remitting-Multiple Sclerosis Patients |
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| المؤلفون: | D'Angelo C, Reale M, Costantini E, Di Nicola M, Porfilio I, de Andrés C, Fernández-Paredes L, Sánchez-Ramón S, Pasquali L. |
| المساهمون: | D'Angelo, C, Reale, M, Costantini, E, Di Nicola, M, Porfilio, I, de Andrés, C, Fernández-Paredes, L, Sánchez-Ramón, S, Pasquali, L. |
| سنة النشر: | 2018 |
| المجموعة: | ARPI - Archivio della Ricerca dell'Università di Pisa |
| مصطلحات موضوعية: | adipokine, inflammasome, interferon-β therapy, multiple sclerosi, pro-inflammatory cytokines |
| الوصف: | BACKGROUND: Multiple sclerosis (MS) is a chronic, progressive autoimmune disease of the central nervous system in which inflammation plays a key role in the induction, development, and progression. Most of the MS patients present with relapsing-remitting (RR) form, characterized by flare-ups followed by periods of recovery. Many inflammatory and anti-inflammatory cytokines have been proposed as backers in MS pathogenesis, and the balance between these differing cytokines can regulate MS severity. Interferon (IFN)-β, a current disease-modifying therapy for MS, has demonstrated beneficial effects in reducing disease severity in MS patients. However, its immunoregulatory and anti-inflammatory actions in MS are not wholly understood. The aim of the study was to define, in clinically stable patients with RR-MS, the serum concentration of several cytokines, canonical or not, and their modulation by IFN-β therapy. METHODS: Relapsing-remitting-MS patients were enrolled and diagnosed according to revised Mc Donald Diagnostic Criteria. A set of cytokines [including non-canonical neurotransmitter acetylcholine (ACh) and adipokines] and B-cell differentiation molecules, as potential biomarkers, were evaluated in 30 non-treated RR-MS patients compared to 30 IFN-β-treated MS patients and 30 age, gender, and body mass index-matched healthy controls (HC). RESULTS: Naïve MS patients showed significantly higher levels of interleukin (IL)-1β, IL-12/IL-23p40, IL-18, high-mobility group box protein-1, and IL-18 binding protein (IL-18BP) than MS-treated patients (p < 0.001 for all) and HC (p < 0.01). IFN-β therapy has significantly downmodulated IL-1β, IL-12/IL-23p40, IL-18 to normal levels (p < 0.001), whereas it has decreased IL-18BP (p < 0.001). ACh was significantly higher in the IFN-β-treated than HC and non-treated MS patients (p < 0.001). No significant differences were observed either in adipokines concentration or in B-cell-associated molecules among the three study groups. CONCLUSION: Although more ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | STAMPA |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/29915590; info:eu-repo/semantics/altIdentifier/wos/WOS:000434044400001; volume:9; firstpage:1; lastpage:10; numberofpages:10; journal:FRONTIERS IN IMMUNOLOGY; http://hdl.handle.net/11568/937160Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85048112303; https://www.frontiersin.org/articles/10.3389/fimmu.2018.01240/fullTest |
| DOI: | 10.3389/fimmu.2018.01240 |
| DOI: | 10.3389/fimmu.2018.01240/full |
| الإتاحة: | https://doi.org/10.3389/fimmu.2018.01240Test http://hdl.handle.net/11568/937160Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.8DE62805 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3389/fimmu.2018.01240 |
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