دورية أكاديمية
Pluripotency reprogramming by competent and incompetent POU factors uncovers temporal dependency for Oct4 and Sox2
| العنوان: | Pluripotency reprogramming by competent and incompetent POU factors uncovers temporal dependency for Oct4 and Sox2 |
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| المؤلفون: | Vikas Malik, Laura V. Glaser, Dennis Zimmer, Sergiy Velychko, Mingxi Weng, Markus Holzner, Marius Arend, Yanpu Chen, Yogesh Srivastava, Veeramohan Veerapandian, Zahir Shah, Miguel A. Esteban, Huating Wang, Jiekai Chen, Hans R. Schöler, Andrew P. Hutchins, Sebastiaan H. Meijsing, Sebastian Pott, Ralf Jauch |
| المصدر: | Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019) |
| بيانات النشر: | Nature Portfolio |
| سنة النشر: | 2019 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | Science |
| الوصف: | Oct4, along with Sox2 and Klf4 can induce pluripotency, but structurally similar factors like Oct6 cannot. Here, using pluripotency competent and incompetent factors, the authors show that Sox2 plays a dominant role in facilitating chromatin opening at Oct4 bound DNA early during reprogramming to pluripotency. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2041-1723 |
| العلاقة: | https://doi.org/10.1038/s41467-019-11054-7Test; https://doaj.org/toc/2041-1723Test; https://doaj.org/article/5d839fd6128d4d118a7cbf72a69b4f17Test |
| DOI: | 10.1038/s41467-019-11054-7 |
| الإتاحة: | https://doi.org/10.1038/s41467-019-11054-7Test https://doaj.org/article/5d839fd6128d4d118a7cbf72a69b4f17Test |
| رقم الانضمام: | edsbas.8DB31C50 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 20411723 |
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| DOI: | 10.1038/s41467-019-11054-7 |