دورية أكاديمية
Preoperative N-terminal pro-B-type natriuretic peptide concertation and prognosis of brain tumor patients: a 5-year follow up study
| العنوان: | Preoperative N-terminal pro-B-type natriuretic peptide concertation and prognosis of brain tumor patients: a 5-year follow up study |
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| المؤلفون: | Bunevičius, Adomas, Deltuva, Vytenis Pranas, Laws, Edward R, Iervasi, Giorgio, Tamašauskas, Arimantas, Bunevičius, Robertas |
| المصدر: | Scientific reports, London : Nature Publishing Group, 2017, vol. 7, no. 1, 14775, p. 1-8 ; eISSN 2045-2322 |
| سنة النشر: | 2017 |
| المجموعة: | LAEI VL (Lithuanian Institute of Agrarian Economics Virtual Library) / LAEI VB (Lietuvos agrarinės ekonomikos institutasvirtualią biblioteką) |
| مصطلحات موضوعية: | Brain tumor, Surgery, N-terminal pro-B-type natriuretic peptide (NT-proBNP) concentration, info:eu-repo/classification/udc/616.831-006.6 |
| الوصف: | Increased N-terminal pro-B-type natriuretic peptide (NT-proBNP) concentration predicts poor prognosis of non-CNS cancer patients. We evaluated the association of NT-proBNP concentration with disease severity, discharge outcomes and prognosis of patients undergoing craniotomy for brain tumor. From January, 2010 until September, 2011 two-hundred and forty-five patients (age 55.05 ± 14.62 years) admitted for brain tumor surgery were evaluated for NT-proBNP serum concentration. Outcome at hospital discharge was evaluated with the Glasgow Outcome Scale (GOS). Most common diagnoses were meningioma (37%) and high-grade glioma (20%). Greater NT-proBNP concentration was associated with lower Barthel index (rho = -0.305, p = 0.001) and Mini Mental State Examination scores (rho = -0.314, p = 0.001) and with greater Hospital Anxiety and Depression scale Depression score (rho = 0.240, p = 0.026). Greater admission NT-proBNP concentration was associated with lower discharge GOS score after adjusting for patient age, gender and histological brain tumor diagnosis (β = -0.253, p < 0.001). Greater NT-proBNP concentration was also associated with greater 5-year mortality risk (HR = 1.845; 95%CI [1.166-2.920], p = 0.009) controlling for patient age, gender, history of cardiovascular disease, histological diagnosis and adjuvant therapy. In sum, greater pre-operative NT-proBNP concentration is associated with worse health status, unfavorable discharge outcome and shorter survival of brain tumor patients. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | http://lsmu.lvb.lt/LSMU:ELABAPDB24611496&prefLang=en_USTest |
| الإتاحة: | https://doi.org/10.1038/s41598-017-15394-6Test http://lsmu.lvb.lt/LSMU:ELABAPDB24611496&prefLang=en_USTest |
| رقم الانضمام: | edsbas.8D14A763 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |