التفاصيل البيبلوغرافية
| العنوان: |
Schematic representation of signaling pathways pSTAT3 and pSmad2 effects in the CA1 region after IR injury, in response to LepA IA injection via ipsilateral ICA at reperfusion. |
| المؤلفون: |
Amit Benbenishty (6524375), Jacob Schneiderman (5851292) |
| سنة النشر: |
2022 |
| المجموعة: |
Smithsonian Institution: Digital Repository |
| مصطلحات موضوعية: |
Biochemistry, Medicine, Cell Biology, Genetics, Molecular Biology, Neuroscience, Physiology, Immunology, Developmental Biology, Cancer, Infectious Diseases, injured brain area, lesions derive expression, leptin therapy may, dose leptin antagonist, +inhibition%22">xlink "> inhibition, saline solution via, injected mice completed, hippocampal ca1 region, blocking leptin activity, also involves processes, leptin antagonist treatment, reperfusion , reperfusion reduced apoptosis, leptin antagonist, %22">xlink ">, leptin activity, ca1 region, treatment reduced, local expression |
| الوصف: |
( A ) Without treatment, leptin overexpression induced by IR injury attaches to upregulated LepRs to form an active complex, while following LepA IA treatment most LepRs are occupied by LepA molecules. ( B ) Without LepA treatment the leptin-LepR complex (black arrows) induces pSTAT3 upregulation and subsequent caspase3 expression (apoptosis) and inflammation. The outcome of this cascade is increased cell death. However, LepA treatment (blue arrows), prevents leptin-LepR complex formation, resulting in reduced pSTAT3, caspase3, and inflammation. Subsequently, the outcome of LepA treatment at reperfusion is neuronal cell preservation. |
| نوع الوثيقة: |
still image |
| اللغة: |
unknown |
| العلاقة: |
https://figshare.com/articles/figure/Schematic_representation_of_signaling_pathways_pSTAT3_and_pSmad2_effects_in_the_CA1_region_after_IR_injury_in_response_to_LepA_IA_injection_via_ipsilateral_ICA_at_reperfusion_/18175435Test |
| DOI: |
10.1371/journal.pone.0261644.g005 |
| الإتاحة: |
https://doi.org/10.1371/journal.pone.0261644.g005Test |
| حقوق: |
CC BY 4.0 |
| رقم الانضمام: |
edsbas.8D133C36 |
| قاعدة البيانات: |
BASE |
