دورية أكاديمية
The relationship between gray/white matter contrast and cognitive performance in first-episode schizophrenia
| العنوان: | The relationship between gray/white matter contrast and cognitive performance in first-episode schizophrenia |
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| المؤلفون: | Kobayashi, Haruko, Sasabayashi, Daiki, Takahashi, Tsutomu, Furuichi, Atsushi, Kido, Mikio, Takayanagi, Yoichiro, Noguchi, Kyo, Suzuki, Michio |
| المساهمون: | JSPS KAKENHI, Health and Labour Science Research Grants for Comprehensive Research, Japan Agency for Medical Research and Development |
| المصدر: | Cerebral Cortex ; volume 34, issue 2 ; ISSN 1047-3211 1460-2199 |
| بيانات النشر: | Oxford University Press (OUP) |
| سنة النشر: | 2024 |
| مصطلحات موضوعية: | Cellular and Molecular Neuroscience, Cognitive Neuroscience |
| الوصف: | Previous postmortem brain studies have revealed disturbed myelination in the intracortical regions in patients with schizophrenia, possibly reflecting anomalous brain maturational processes. However, it currently remains unclear whether this anomalous myelination is already present in early illness stages and/or progresses during the course of the illness. In this magnetic resonance imaging study, we examined gray/white matter contrast (GWC) as a potential marker of intracortical myelination in 63 first-episode schizophrenia (FESz) patients and 77 healthy controls (HC). Furthermore, we investigated the relationships between GWC findings and clinical/cognitive variables in FESz patients. GWC in the bilateral temporal, parietal, occipital, and insular regions was significantly higher in FESz patients than in HC, which was partly associated with the durations of illness and medication, the onset age, and lower executive and verbal learning performances. Because higher GWC implicates lower myelin in the deeper layers of the cortex, these results suggest that schizophrenia patients have less intracortical myelin at the time of their first psychotic episode, which underlies lower cognitive performance in early illness stages. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1093/cercor/bhae009 |
| الإتاحة: | https://doi.org/10.1093/cercor/bhae009Test https://academic.oup.com/cercor/article-pdf/34/2/bhae009/56572909/bhae009.pdfTest |
| حقوق: | https://academic.oup.com/pages/standard-publication-reuse-rightsTest |
| رقم الانضمام: | edsbas.8CC544D5 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/cercor/bhae009 |
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