التفاصيل البيبلوغرافية
| العنوان: |
Prognosis of Paradoxical Low-Flow Low-Gradient Aortic Stenosis : A Severe, Non-critical Form, With Surgical Treatment Benefits |
| المؤلفون: |
Galian-Gay, Laura, Escalona Silva, Roxana Andreina, Teixido-Tura, Gisela, Casas, Guillem, Ferrer-Sistach, Elena, Mitroi, Cristina, Mingo, Susana, Monivas, Vanessa, Saura, Daniel, Vidal, Bà rbara, Trasca, Livia, Moral Torres, Sergio, Calvo Iglesias, Francisco, Castiñeira Busto, Maria, Sánchez, Violeta, Gonzalez, Ariana, Guzman, Gabriela, Mora, Marta Noris, Arnau Vives, Miguel Ãngel, Peteiro, Jesús, Bouzas, Alberto, Mas-Stachurska, Aleksandra, González-Alujas, Teresa, Gutiérrez GarcÃa-Moreno, Laura, Fernandez-Galera, Rubén, Valente, Filipa, Guala, Andrea, Ruiz-Muñoz, Aroa, Sao-Avilés, Augusto, Rodriguez-Palomares, Jose F, Ferreira-Gonzalez, Ignacio, Evangelista, Artur, Universitat Autònoma de Barcelona |
| سنة النشر: |
2022 |
| المجموعة: |
Universitat Autònoma de Barcelona: Dipòsit Digital de Documents de la UAB |
| مصطلحات موضوعية: |
Aortic stenosis, Paradoxical low-flow low-gradient, Echocardiography, Aortic valve surgery, Heart valve disease |
| الوصف: |
To determine the risk of mortality and need for aortic valve replacement (AVR) in patients with low-flow low-gradient (LFLG) aortic stenosis (AS). A longitudinal multicentre study including consecutive patients with severe AS (aortic valve area [AVA] < 1.0 cm 2) and normal left ventricular ejection fraction (LVEF). Patients were classified as: high-gradient (HG, mean gradient ≥ 40 mmHg), normal-flow low-gradient (NFLG, mean gradient < 40 mmHg, indexed systolic volume (SVi) > 35 ml/m 2) and LFLG (mean gradient < 40 mmHg, SVi ≤ 35 ml/m 2). Of 1,391 patients, 147 (10.5%) had LFLG, 752 (54.1%) HG, and 492 (35.4%) NFLG. Echocardiographic parameters of the LFLG group showed similar AVA to the HG group but with less severity in the dimensionless index, calcification, and hypertrophy. The HG group required AVR earlier than NFLG (p < 0.001) and LFLG (p < 0.001), with no differences between LFLG and NFLG groups (p = 0.358). Overall mortality was 27.7% (CI 95% 25.3-30.1) with no differences among groups (p = 0.319). The impact of AVR in terms of overall mortality reduction was observed the most in patients with HG (hazard ratio [ HR ]: 0.17; 95% CI : 0.12-0.23; p < 0.001), followed by patients with LFLG (HR : 0.25; 95% CI : 0.13-0.49; p < 0.001), and finally patients with NFLG (HR : 0.29; 95% CI : 0.20-0.44; p < 0.001), with a risk reduction of 84, 75, and 71%, respectively. Paradoxical LFLG AS affects 10.5% of severe AS, and has a lower need for AVR than the HG group and similar to the NFLG group, with no differences in mortality. AVR had a lower impact on LFLG AS compared with HG AS. Therefore, the findings of the present study showed LFLG AS to have an intermediate clinical risk profile betwee the HG and NFHG groups |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| العلاقة: |
Ministerio de Ciencia e Innovación IJC2018- 037349-I; Frontiers in Cardiovascular Medicine; Vol. 9 (april 2022); https://ddd.uab.cat/record/258078Test; urn:10.3389/fcvm.2022.852954; urn:oai:ddd.uab.cat:258078; urn:pmcid:PMC9011160; urn:pmc-uid:9011160; urn:pmid:35433871; urn:oai:pubmedcentral.nih.gov:9011160; urn:oai:egreta.uab.cat:publications/5e54c2b2-83e7-4917-b1f2-de2c3f0a3847 |
| الإتاحة: |
https://ddd.uab.cat/record/258078Test |
| حقوق: |
open access ; Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. ; https://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: |
edsbas.8C7A6093 |
| قاعدة البيانات: |
BASE |
