التفاصيل البيبلوغرافية
| العنوان: |
No evidence of association between inherited thrombophilia and increased risk of liver fibrosis |
| المؤلفون: |
Ezcurra, Iranzu, Puente, Ángela, Cuadrado, Antonio, Tamayo, Ibai, Iruzubieta, Paula, Arias‐Loste, María Teresa, González, Francisco José, Pellón, Raúl, Sánchez, Sara, Crespo, Juan, Acebo, Mercedes, López‐Hoyos, Marcos, Pérez, Rocío, Cuesta, Amalia, Antón, Ángela, Echavarría, Víctor, Fábrega, Emilio, Crespo, Javier, Fortea, Jose Ignacio |
| المساهمون: |
Instituto de Salud Carlos III |
| المصدر: |
United European Gastroenterology Journal ; volume 11, issue 10, page 1010-1020 ; ISSN 2050-6406 2050-6414 |
| بيانات النشر: |
Wiley |
| سنة النشر: |
2023 |
| المجموعة: |
Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: |
Background Preliminary evidence suggests that inherited hypercoagulable disorders can lead to an increased risk of significant liver fibrosis. Objective We aimed to investigate the prevalence of significant fibrosis in patients with inherited thrombophilia, assessed by using liver stiffness (LS), and to compare this prevalence to that found in a large population‐based cohort from the same region. Methods This was a single‐center, cross‐sectional study. A complete laboratory analysis for liver disease, LS by transient elastography and an abdominal ultrasound were performed in patients with inherited thrombophilia diagnosed between May 2013‐February 2017. These patients were propensity score matched (ratio 1:4) with a population‐based cohort from the same region (PREVHEP‐ETHON study; NCT02749864; N = 5988). Results Of 241 patients with inherited thrombophilia, eight patients (3.3%) had significant fibrosis (LS ≥8 kPa). All of them had risk factors for liver disease and met diagnostic criteria for different liver diseases. After matching 221 patients with thrombophilia with 884 patients of the PREVHEP‐ETHON cohort, the prevalence of significant fibrosis was similar between both cohorts (1.8% vs. 3.6%, p = 0.488). Multivariate analysis showed that age and liver disease risk factors, but not belonging to the thrombophilia cohort, were associated with the presence of significant fibrosis. The magnitude of the increased risk of significant fibrosis in patients with risk factors for liver disease was also similar in both cohorts. Conclusions Our findings do not provide evidence supporting an association between inherited thrombophilia and an increased risk of significant liver fibrosis, independent of the presence of liver‐related causes of fibrosis. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.1002/ueg2.12500 |
| الإتاحة: |
https://doi.org/10.1002/ueg2.12500Test |
| حقوق: |
http://creativecommons.org/licenses/by-nc-nd/4.0Test/ |
| رقم الانضمام: |
edsbas.8C0FAC1F |
| قاعدة البيانات: |
BASE |
