دورية أكاديمية
Emergent seesaw oscillations during cellular directional decision-making
| العنوان: | Emergent seesaw oscillations during cellular directional decision-making |
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| المؤلفون: | Ron, Jonathan E., Crestani, Michele, id_orcid:0 000-0002-5089-6664, Kux, Johan M., Liu, Jiayi, Al-Dam, Nabil, Monzo, Pascale, Gauthier, Nils C., Sáez, Pablo J., Gov, Nir S. |
| المصدر: | Nature Physics |
| بيانات النشر: | Nature |
| سنة النشر: | 2024 |
| المجموعة: | ETH Zürich Research Collection |
| الوصف: | Motile cells inside living tissues often encounter junctions, where their path branches into several alternative directions of migration. We present a theoretical model of cellular polarization for a cell migrating along a one-dimensional line, arriving at a symmetric Y junction and extending protrusions along the different paths that originate at the junction. The model predicts the spontaneous emergence of deterministic oscillations of growth and cellular polarization between competing protrusions during the directional decision-making process. The oscillations are modified by cellular noise but remain a dominant feature that affects the time it takes the cell to migrate across the junction. These predictions are confirmed experimentally for two different cell types (non-cancerous endothelial and cancerous glioma cells) migrating on a patterned network of thin adhesive lanes with junctions. ; Cell motion along linear confinements is deterministic. Now a model predicts deterministic oscillations in cellular polarization at a Y junction in a set-up with adhesive patterns. ; ISSN:1745-2473 ; ISSN:1745-2481 |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/application/pdf |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/wos/001144472300001; http://hdl.handle.net/20.500.11850/656434Test |
| DOI: | 10.3929/ethz-b-000656434 |
| الإتاحة: | https://doi.org/20.500.11850/656434Test https://doi.org/10.3929/ethz-b-000656434Test https://doi.org/10.1038/s41567-023-02335-6Test https://hdl.handle.net/20.500.11850/656434Test |
| حقوق: | info:eu-repo/semantics/openAccess ; http://creativecommons.org/licenses/by/4.0Test/ ; Creative Commons Attribution 4.0 International |
| رقم الانضمام: | edsbas.8BB0DBC7 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3929/ethz-b-000656434 |
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