التفاصيل البيبلوغرافية
| العنوان: |
Antibiotic‐producing Micrococcales govern the microbiome that inhabits the fur of two‐ and three‐toed sloths |
| المؤلفون: |
Rojas‐Gätjens, Diego, Valverde‐Madrigal, Katherine S., Rojas‐Jimenez, Keilor, Pereira, Reinaldo, Avey‐Arroyo, Judy, Chavarría, Max |
| المساهمون: |
Vicerrectoría de Investigación, Universidad de Costa Rica |
| المصدر: |
Environmental Microbiology ; volume 24, issue 7, page 3148-3163 ; ISSN 1462-2912 1462-2920 |
| بيانات النشر: |
Wiley |
| سنة النشر: |
2022 |
| المجموعة: |
Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: |
Summary Sloths have a dense coat on which insects, algae and fungi coexist in a symbiotic relationship. This complex ecosystem requires different levels of controls; however, most of these mechanisms remain unknown. We investigated the bacterial communities inhabiting the hair of two‐ ( Choloepus Hoffmanni ) and three‐toed ( Bradypus variegatus ) sloths and evaluated their potential for producing antibiotic molecules capable of exerting control over the hair microbiota. The analysis of 16S rRNA amplicon sequence variants revealed that the communities in both host species are dominated by Actinobacteriota and Firmicutes. The most abundant genera were Brevibacterium , Kocuria/Rothia , Staphylococcus , Rubrobacter , Nesterenkonia and Janibacter . Furthermore, we isolated nine strains of Brevibacterium and Rothia capable of producing substances that inhibited the growth of common mammalian pathogens. The analysis of the biosynthetic gene clusters of these nine isolates suggests that the pathogen‐inhibitory activity could be mediated by the presence of siderophores, terpenes, beta‐lactones, Type III polyketide synthases, ribosomally synthesized and post‐translationally modified peptides, non‐alpha poly‐amino acids like e‐Polylysine, ectoine or non‐ribosomal peptides. Our data suggest that Micrococcales that inhabit sloth hair could have a role in controlling microbial populations in that habitat, improving our understanding of this highly complex ecosystem. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.1111/1462-2920.16082 |
| الإتاحة: |
https://doi.org/10.1111/1462-2920.16082Test |
| حقوق: |
http://onlinelibrary.wiley.com/termsAndConditions#vorTest |
| رقم الانضمام: |
edsbas.8B4B6138 |
| قاعدة البيانات: |
BASE |
