دورية أكاديمية
CD4+ T cells in classical Hodgkin lymphoma express exhaustion associated transcription factors TOX and TOX2:Characterizing CD4+ T cells in Hodgkin lymphoma
| العنوان: | CD4+ T cells in classical Hodgkin lymphoma express exhaustion associated transcription factors TOX and TOX2:Characterizing CD4+ T cells in Hodgkin lymphoma |
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| المؤلفون: | Veldman, Johanna, Placa, Jessica Rodrigues, Chong, Lauren, Terpstra, Miente Martijn, Mastik, Mirjam, van Kempen, Leon C., Kok, Klaas, Aoki, Tomohiro, Steidl, Christian, van den Berg, Anke, Visser, Lydia, Diepstra, Arjan |
| المصدر: | Veldman , J , Placa , J R , Chong , L , Terpstra , M M , Mastik , M , van Kempen , L C , Kok , K , Aoki , T , Steidl , C , van den Berg , A , Visser , L & Diepstra , A 2022 , ' CD4+ T cells in classical Hodgkin lymphoma express exhaustion associated transcription factors TOX and TOX2 : Characterizing CD4+ T cells in Hodgkin lymphoma ' , OncoImmunology , vol. 11 , no. 1 , 2033433 . https://doi.org/10.1080/2162402X.2022.2033433Test |
| سنة النشر: | 2022 |
| المجموعة: | University of Groningen research database |
| مصطلحات موضوعية: | Hodgkin, CD26, polyclonal, exhaustion, TOX, REED-STERNBERG CELLS, TUMOR MICROENVIRONMENT, ANALYSIS REVEALS, T-CELLS, DISEASE, PREDOMINANCE, LYMPHOCYTES, CYTOMETRY, BLOCKADE, NODES |
| الوصف: | In classical Hodgkin lymphoma (cHL), the highly abundant CD4+ T cells in the vicinity of tumor cells are considered essential for tumor cell survival, but are ill-defined. Although they are activated, they consistently lack expression of activation marker CD26. In this study, we compared sorted CD4+CD26- and CD4+CD26+ T cells from cHL lymph node cell suspensions by RNA sequencing and T cell receptor variable gene segment usage analysis. This revealed that although CD4+CD26- T cells are antigen experienced, they have not clonally expanded. This may well be explained by the expression of exhaustion associated transcription factors TOX and TOX2, immune checkpoints PDCD1 and CD200, and chemokine CXCL13, which were amongst the 100 significantly enriched genes in comparison with the CD4+CD26+ T cells. Findings were validated in single-cell RNA sequencing data from an independent cohort. Interestingly, immunohistochemistry revealed predominant and high frequency of staining for TOX and TOX2 in the T cells attached to the tumor cells. In conclusion, the dominant CD4+CD26- T cell population in cHL is antigen experienced, polyclonal, and exhausted. This population is likely a main contributor to the very high response rates to immune checkpoint inhibitors in cHL. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | https://research.rug.nl/en/publications/dcbef0e2-ee23-4bc3-a610-2d2ed79db022Test |
| DOI: | 10.1080/2162402X.2022.2033433 |
| الإتاحة: | https://doi.org/10.1080/2162402X.2022.2033433Test https://hdl.handle.net/11370/dcbef0e2-ee23-4bc3-a610-2d2ed79db022Test https://research.rug.nl/en/publications/dcbef0e2-ee23-4bc3-a610-2d2ed79db022Test https://pure.rug.nl/ws/files/202241293/2162402X.2022.pdfTest |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.8B3469DC |
| قاعدة البيانات: | BASE |
| DOI: | 10.1080/2162402X.2022.2033433 |
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