دورية أكاديمية
Neuromodulation of striatal D1 cells shapes BOLD fluctuations in anatomically connected thalamic and cortical regions
| العنوان: | Neuromodulation of striatal D1 cells shapes BOLD fluctuations in anatomically connected thalamic and cortical regions |
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| المؤلفون: | Markicevic, Marija, Sturman, Oliver, Bohacek, Johannes, id_orcid:0 000-0002-8442-653X, Rudin, Markus, Zerbi, Valerio, Fulcher, Ben D., Wenderoth, Nicole |
| المصدر: | eLife, 12 |
| بيانات النشر: | eLife Sciences Publications |
| سنة النشر: | 2023 |
| المجموعة: | ETH Zürich Research Collection |
| الوصف: | Understanding how the brain’s macroscale dynamics are shaped by underlying microscale mechanisms is a key problem in neuroscience. In animal models, we can now investigate this relationship in unprecedented detail by directly manipulating cellular-level properties while measuring the whole-brain response using resting-state fMRI. Here, we focused on understanding how blood-oxygen-level-dependent (BOLD) dynamics, measured within a structurally well-defined striato-thalamo-cortical circuit in mice, are shaped by chemogenetically exciting or inhibiting D1 medium spiny neurons (MSNs) of the right dorsomedial caudate putamen (CPdm). We characterize changes in both the BOLD dynamics of individual cortical and subcortical brain areas, and patterns of inter-regional coupling (functional connectivity) between pairs of areas. Using a classification approach based on a large and diverse set of time-series properties, we found that CPdm neuromodulation alters BOLD dynamics within thalamic subregions that project back to dorsomedial striatum. In the cortex, changes in local dynamics were strongest in unimodal regions (which process information from a single sensory modality) and weakened along a hierarchical gradient towards transmodal regions. In contrast, a decrease in functional connectivity was observed only for corticostriatal connections after D1 excitation. Our results show that targeted cellular-level manipulations affect local BOLD dynamics at the macroscale, such as by making BOLD dynamics more predictable over time by increasing its self-correlation structure. This contributes to ongoing attempts to understand the influence of structure–function relationships in shaping inter-regional communication at subcortical and cortical levels. ; ISSN:2050-084X |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/application/pdf |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/wos/001134835400001; info:eu-repo/grantAgreement/ETHZ/ETH Grants/ETH-38 16-2; http://hdl.handle.net/20.500.11850/650255Test |
| DOI: | 10.3929/ethz-b-000650255 |
| الإتاحة: | https://doi.org/20.500.11850/650255Test https://doi.org/10.3929/ethz-b-000650255Test https://doi.org/10.7554/elife.78620Test https://hdl.handle.net/20.500.11850/650255Test |
| حقوق: | info:eu-repo/semantics/openAccess ; http://creativecommons.org/licenses/by/4.0Test/ ; Creative Commons Attribution 4.0 International |
| رقم الانضمام: | edsbas.8B0B6FB9 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3929/ethz-b-000650255 |
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