التفاصيل البيبلوغرافية
| العنوان: |
MORC proteins regulate transcription factor binding by mediating chromatin compaction in active chromatin regions |
| المؤلفون: |
Zhong, Zhenhui, Xue, Yan, Harris, C Jake, Wang, Ming, Li, Zheng, Ke, Yunqing, Liu, Mukun, Zhou, Jessica, Jami-Alahmadi, Yasaman, Feng, Suhua, Wohlschlegel, James A, Jacobsen, Steven E |
| المصدر: |
Genome Biology, vol 24, iss 1 |
| بيانات النشر: |
eScholarship, University of California |
| سنة النشر: |
2023 |
| المجموعة: |
University of California: eScholarship |
| مصطلحات موضوعية: |
Biochemistry and Cell Biology, Bioinformatics and Computational Biology, Biological Sciences, Genetics, Plant Biology, Underpinning research, 1.1 Normal biological development and functioning, Generic health relevance, Chromatin, Arabidopsis, Arabidopsis Proteins, Gene Silencing, Transcription Factors, DNA Methylation, Gene Expression Regulation, Plant, Microrchidia, MORC, Chromatin compaction, TF binding, Transcription regulation, Environmental Sciences, Information and Computing Sciences, Bioinformatics |
| الوصف: |
BackgroundThe microrchidia (MORC) proteins are a family of evolutionarily conserved GHKL-type ATPases involved in chromatin compaction and gene silencing. Arabidopsis MORC proteins act in the RNA-directed DNA methylation (RdDM) pathway, where they act as molecular tethers to ensure the efficient establishment of RdDM and de novo gene silencing. However, MORC proteins also have RdDM-independent functions although their underlying mechanisms are unknown.ResultsIn this study, we examine MORC binding regions where RdDM does not occur in order to shed light on the RdDM-independent functions of MORC proteins. We find that MORC proteins compact chromatin and reduce DNA accessibility to transcription factors, thereby repressing gene expression. We also find that MORC-mediated repression of gene expression is particularly important under conditions of stress. MORC-regulated transcription factors can in some cases regulate their own transcription, resulting in feedback loops.ConclusionsOur findings provide insights into the molecular mechanisms of MORC-mediated chromatin compaction and transcription regulation. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
unknown |
| العلاقة: |
qt6zh4m400; https://escholarship.org/uc/item/6zh4m400Test |
| الإتاحة: |
https://escholarship.org/uc/item/6zh4m400Test |
| حقوق: |
public |
| رقم الانضمام: |
edsbas.8AFB44C0 |
| قاعدة البيانات: |
BASE |
