دورية أكاديمية
Comparisons of the Efficacy of Alpha Glucosidase Inhibitors on Type 2 Diabetes Patients between Asian and Caucasian
| العنوان: | Comparisons of the Efficacy of Alpha Glucosidase Inhibitors on Type 2 Diabetes Patients between Asian and Caucasian |
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| المؤلفون: | Cai, Xiaoling, Han, Xueyao, Luo, Yingying, Ji, Linong |
| المساهمون: | Ji, LN (reprint author), Peking Univ, Peoples Hosp, Dept Endocrinol & Metab, Beijing 100871, Peoples R China., Peking Univ, Peoples Hosp, Dept Endocrinol & Metab, Beijing 100871, Peoples R China. |
| المصدر: | PubMed ; SCI |
| بيانات النشر: | plos one |
| سنة النشر: | 2013 |
| المجموعة: | Peking University Institutional Repository (PKU IR) / 北京大学机构知识库 |
| مصطلحات موضوعية: | IMPROVES GLYCEMIC CONTROL, INTIMA-MEDIA THICKNESS, TREATED NIDDM PATIENTS, DOUBLE-BLIND, METABOLIC-CONTROL, ACARBOSE MONOTHERAPY, SULFONYLUREA THERAPY, COMBINATION THERAPY, INSULIN SENSITIVITY, 24-WEEK MONOTHERAPY |
| الوصف: | Background: To compare the efficacy of glycemic control and insulin secretion of alpha glucosidase inhibitors (AGI) on type 2 diabetes patients between Asian and Caucasian. Methodology/Principal Findings: The MEDLINE (R), EMBASE (R), CENTRAL were searched and qualified studies in Asian and Caucasian population comparing AGI treatment with placebo or other oral anti-diabetic drugs in type 2 diabetic patients were included. Totally 58 qualified studies were included. When AGI treatment was compared with placebo, a significant difference in HbA1c decline from baseline favoring AGI treatment was found in Asian (weighted mean difference (WMD), -0.50%; 95% CI, -0.66% to -0.34%) and in Caucasian a significant difference in HbA1c decline favoring AGI treatment was also found (WMD, -0.68%; 95% CI, -0.76% to -0.60%). In Asian, fasting plasma glucose was reduced with AGI treatment compared with placebo (WMD, -0.53 mmol/L; 95% CI, -0.91 to -0.14 mmol/L) and in Caucasian there was also a significant difference in FPG changes favoring AGI therapy (WMD, -0.88 mmol/L; 95% CI, -1.00 to -0.77 mmol/L). Studies in Asian showed a significant difference in fasting insulin changes favoring AGI treatment (WMD, -0.78 uU/ml; 95% CI, -0.96 to -0.59 uU/ml). While in Caucasian fasting insulin was decreased without significance with AGI treatment (WMD-1.24 uU/ml; 95% CI, -2.51 to 0.04 uU/ml). Body weight was decreased with AGI treatment in Asian (WMD, -1.00 kg; 95% CI, -1.69 to -0.31 kg) and was also decreased with AGI treatment in Caucasian (WMD, -0.73 kg; 95% CI, -1.13 to -0.33 kg). Conclusions/Significance: According to results from this meta-analysis, the efficacy in glucose lowering, body weight reduction and insulin secretion decreasing of AGI treatment in Asian were comparable with those in Caucasian. ; Multidisciplinary Sciences ; SCI(E) ; PubMed ; 1 ; ARTICLE ; 11 ; e79421 ; 8 |
| نوع الوثيقة: | journal/newspaper |
| اللغة: | English |
| تدمد: | 1932-6203 |
| العلاقة: | PLOS ONE.2013,8,(11).; 654560; http://hdl.handle.net/20.500.11897/159213Test; WOS:000327254700130 |
| DOI: | 10.1371/journal.pone.0079421 |
| الإتاحة: | https://doi.org/20.500.11897/159213Test https://doi.org/10.1371/journal.pone.0079421Test https://hdl.handle.net/20.500.11897/159213Test |
| رقم الانضمام: | edsbas.8AC2A537 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 19326203 |
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| DOI: | 10.1371/journal.pone.0079421 |