دورية أكاديمية
Hedonic sensitivity to natural rewards is affected by prenatal stress in a sex-dependent manner
| العنوان: | Hedonic sensitivity to natural rewards is affected by prenatal stress in a sex-dependent manner |
|---|---|
| المؤلفون: | Reynaert, Marie-Line, Marrocco, Jordan, Mairesse, Jérôme, Lionetto, Luana, Simmaco, Maurizio, Deruyter, Lucie, Allorge, Delphine, Moles, Anna, Pittaluga, Anna, Maccari, Stefania, MORLEY-FLETCHER, Sara, Van Camp, Gilles, Nicoletti, Ferdinando |
| المساهمون: | CHU Lille, CNRS, Université de Lille, Institut Pasteur de Lille, Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 UGSF, Istituto Neurologico Mediterraneo NEUROMED I.R.C.C.S., Centro Neurolesi Bonino Pulejo Messina IRCCS Messina, Azienda Ospedaliera Sant'Andrea Roma, 171461|||Impact de l'environnement chimique sur la santé humaine - ULR 4483 IMPECS, 235067, Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576, IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - EA 4483 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2021 |
| المجموعة: | LillOA (Lille Open Archive - Université de Lille) |
| مصطلحات موضوعية: | Animal model, conditioned place preference, early life stress, palatable food, sex hormones |
| الوصف: | Palatable food is a strong activator of the reward circuitry and may cause addictive behavior leading to eating disorders. How early life events and sex interact in shaping hedonic sensitivity to palatable food is largely unknown. We used prenatally restraint stressed (PRS) rats, which show abnormalities in the reward system and anxious/depressive-like behavior. Some of the hallmarks of PRS rats are known to be sex-dependent. We report that PRS enhanced and reduced milk chocolate-induced conditioned place preference in males and females, respectively. Male PRS rats also show increases in plasma dihydrotestosterone (DHT) levels and dopamine (DA) levels in the nucleus accumbens (NAc), and reductions in 5-hydroxytryptamine (5-HT) levels in the NAc and prefrontal cortex (PFC). In male rats, systemic treatment with the DHT-lowering drug finasteride reduced both milk chocolate preference and NAc DA levels. Female PRS rats showed lower plasma estradiol (E2) levels and lower DA levels in the NAc, and 5-HT levels in the NAc and PFC. E2 supplementation reversed the reduction in milk chocolate preference and PFC 5-HT levels. In the hypothalamus, PRS increased ERα and ERβ estrogen receptor and CARTP (cocaine-and-amphetamine receptor transcript peptide) mRNA levels in males, and 5-HT2C receptor mRNA levels in females. Changes were corrected by treatments with finasteride and E2, respectively. These new findings show that early life stress has a profound impact on hedonic sensitivity to high-palatable food via long-lasting changes in gonadal hormones. This paves the way to the development of hormonal strategies aimed at correcting abnormalities in the response to natural rewards. ; 21;6 |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/octet-stream |
| اللغة: | English |
| العلاقة: | Addiction Biology; http://hdl.handle.net/20.500.12210/18436Test |
| الإتاحة: | https://doi.org/20.500.12210/18436Test https://hdl.handle.net/20.500.12210/18436Test |
| حقوق: | info:eu-repo/semantics/closedAccess |
| رقم الانضمام: | edsbas.8A770CB5 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |