التفاصيل البيبلوغرافية
| العنوان: |
Genomic survey of prepulse inhibition in mouse chromosome substitution strains |
| المؤلفون: |
Leussis, M. P., Frayne, M. L., Saito, M., Berry, E. M., Aldinger, K. A., Rockwell, G. N., Hammer Jr, R. P., Baskin‐Hill, A. E., Singer, J. B., Nadeau, J. H., Sklar, P., Petryshen, T. L. |
| المصدر: |
Genes, Brain and Behavior ; volume 8, issue 8, page 806-816 ; ISSN 1601-1848 1601-183X |
| بيانات النشر: |
Wiley |
| سنة النشر: |
2009 |
| المجموعة: |
Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: |
Prepulse inhibition (PPI) is a measure of sensorimotor gating, a pre‐attentional inhibitory brain mechanism that filters extraneous stimuli. Prepulse inhibition is correlated with measures of cognition and executive functioning, and is considered an endophenotype of schizophrenia and other psychiatric illnesses in which patients show PPI impairments. As a first step toward identifying genes that regulate PPI, we performed a quantitative trait locus (QTL) screen of PPI phenotypes in a panel of mouse chromosome substitution strains (CSSs). We identified five CSSs with altered PPI compared with the host C57BL/6J strain: CSS‐4 exhibited decreased PPI, whereas CSS‐10, ‐11, ‐16 and ‐Y exhibited higher PPI compared with C57BL/6J. These data indicate that A/J chromosomes 4, 10, 11, 16 and Y harbor at least one QTL region that modulates PPI in these CSSs. Quantitative trait loci for the acoustic startle response were identified on seven chromosomes. Like PPI, habituation of the startle response is also disrupted in schizophrenia, and in the present study CSS‐7 and ‐8 exhibited deficits in startle habituation. Linkage analysis of an F 2 intercross identified a highly significant QTL for PPI on chromosome 11 between positions 101.5 and 114.4 Mb (peak LOD = 4.54). Future studies will map the specific genes contributing to these QTLs using congenic strains and other genomic approaches. Identification of genes that modulate PPI will provide insight into the neural mechanisms underlying sensorimotor gating, as well as the psychopathology of disorders characterized by gating deficits. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.1111/j.1601-183x.2009.00526.x |
| DOI: |
10.1111/j.1601-183X.2009.00526.x |
| الإتاحة: |
https://doi.org/10.1111/j.1601-183x.2009.00526.xTest |
| حقوق: |
http://onlinelibrary.wiley.com/termsAndConditions#vorTest |
| رقم الانضمام: |
edsbas.8A61BE27 |
| قاعدة البيانات: |
BASE |
