دورية أكاديمية
The long non-coding RNA MIR31HG regulates the senescence associated secretory phenotype
| العنوان: | The long non-coding RNA MIR31HG regulates the senescence associated secretory phenotype |
|---|---|
| المؤلفون: | Montes, Marta, Lubas, Michal, Arendrup, Frederic S., Mentz, Bettina, Rohatgi, Neha, Tumas, Sarunas, Harder, Lea M., Skanderup, Anders J., Andersen, Jens S., Lund, Anders H. |
| المصدر: | Montes , M , Lubas , M , Arendrup , F S , Mentz , B , Rohatgi , N , Tumas , S , Harder , L M , Skanderup , A J , Andersen , J S & Lund , A H 2021 , ' The long non-coding RNA MIR31HG regulates the senescence associated secretory phenotype ' , Nature Communications , vol. 12 , no. 1 , 2459 . https://doi.org/10.1038/s41467-021-22746-4Test |
| سنة النشر: | 2021 |
| المجموعة: | University of Southern Denmark: Research Output / Syddansk Universitet |
| مصطلحات موضوعية: | Aging/genetics, Cell Line, Cell Proliferation/genetics, Cell Transformation, Neoplastic/genetics, Cellular Senescence/genetics, Cyclin-Dependent Kinase Inhibitor p16/biosynthesis, Gene Expression Regulation, Humans, Neoplasms/genetics, Phosphorylation, Proto-Oncogene Proteins B-raf/metabolism, RNA, Long Noncoding/genetics, Ribosomal Protein S6 Kinases, 90-kDa/metabolism, Y-Box-Binding Protein 1/metabolism |
| الوصف: | Oncogene-induced senescence provides a barrier against malignant transformation. However, it can also promote cancer through the secretion of a plethora of factors released by senescent cells, called the senescence associated secretory phenotype (SASP). We have previously shown that in proliferating cells, nuclear lncRNA MIR31HG inhibits p16/CDKN2A expression through interaction with polycomb repressor complexes and that during BRAF-induced senescence, MIR31HG is overexpressed and translocates to the cytoplasm. Here, we show that MIR31HG regulates the expression and secretion of a subset of SASP components during BRAF-induced senescence. The SASP secreted from senescent cells depleted for MIR31HG fails to induce paracrine invasion without affecting the growth inhibitory effect. Mechanistically, MIR31HG interacts with YBX1 facilitating its phosphorylation at serine 102 (p-YBX1 S102 ) by the kinase RSK. p-YBX1 S102 induces IL1A translation which activates the transcription of the other SASP mRNAs. Our results suggest a dual role for MIR31HG in senescence depending on its localization and points to the lncRNA as a potential therapeutic target in the treatment of senescence-related pathologies. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | https://portal.findresearcher.sdu.dk/da/publications/d515a39c-f9b2-445a-b6d8-1805bb7b26bcTest |
| DOI: | 10.1038/s41467-021-22746-4 |
| الإتاحة: | https://doi.org/10.1038/s41467-021-22746-4Test https://portal.findresearcher.sdu.dk/da/publications/d515a39c-f9b2-445a-b6d8-1805bb7b26bcTest https://findresearcher.sdu.dk/ws/files/182422364/s41467_021_22746_4.pdfTest |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.8A5C12A9 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1038/s41467-021-22746-4 |
|---|