التفاصيل البيبلوغرافية
| العنوان: |
Immune Transcriptome and Secretome Differ between Human CD71+ Erythroid Cells from Adult Bone Marrow and Fetal Liver Parenchyma |
| المؤلفون: |
Roman Perik-Zavodskii, Olga Perik-Zavodskaya, Yulia Shevchenko, Vera Denisova, Kirill Nazarov, Irina Obleuhova, Konstantin Zaitsev, Sergey Sennikov |
| المصدر: |
Genes; Volume 13; Issue 8; Pages: 1333 |
| بيانات النشر: |
Multidisciplinary Digital Publishing Institute |
| سنة النشر: |
2022 |
| المجموعة: |
MDPI Open Access Publishing |
| مصطلحات موضوعية: |
CD71 + erythroid cells, bone marrow, fetal liver parenchyma, MIF, IL8, TLR1, TLR2, TLR9, NOD2 |
| جغرافية الموضوع: |
agris |
| الوصف: |
CD71+ erythroid cells (CECs) were only known as erythrocyte progenitors not so long ago. In present times, however, they have been shown to be active players in immune regulation, especially in immunosuppression by the means of ROS, arginase-1 and arginase-2 production. Here, we uncover organ-of-origin differences in cytokine gene expression using NanoString and protein production using Bio-Plex between CECs from healthy human adult bone marrow and from human fetal liver parenchyma. Namely, healthy human adult bone marrow CECs both expressed and produced IFN-a, IL-1b, IL-8, IL-18 and MIF mRNA and protein, while human fetal liver parenchyma CECs expressed and produced IFN-a, IL15, IL18 and TNF-b mRNA and protein. We also detected TLR2 and TLR9 gene expression in both varieties of CECs and TLR1 and NOD2 gene expression in human fetal liver parenchyma CECs only. These observations suggest that there might be undiscovered roles in immune response for CECs. |
| نوع الوثيقة: |
text |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| العلاقة: |
Molecular Genetics and Genomics; https://dx.doi.org/10.3390/genes13081333Test |
| DOI: |
10.3390/genes13081333 |
| الإتاحة: |
https://doi.org/10.3390/genes13081333Test |
| حقوق: |
https://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: |
edsbas.898249A2 |
| قاعدة البيانات: |
BASE |
