دورية أكاديمية
The caveolar membrane system in endothelium: from cell signaling to vascular pathology
| العنوان: | The caveolar membrane system in endothelium: from cell signaling to vascular pathology |
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| المؤلفون: | Antonio Filippini, Gigliola Sica, Alessio D’Alessio |
| المساهمون: | Filippini, Antonio, Sica, Gigliola, D'Alessio, Alessio |
| بيانات النشر: | John Wiley & sons Hoboken |
| سنة النشر: | 2018 |
| المجموعة: | Sapienza Università di Roma: CINECA IRIS |
| مصطلحات موضوعية: | angiogenesi, cancer, caveolae, caveolin, endothelial cell, EPCs |
| الوصف: | Caveolae are 50- to 100-nm cholesterol and glycosphingolipid-rich flask-shaped invaginations commonly observed in many terminally differentiated cells. These organelles have been described in many cell types and are particularly abundant in endothelial cells, where they have been involved in the regulation of certain signaling pathways. Specific scaffolding proteins termed caveolins, along with the more recently discovered members of the cavin family, represent the major protein components during caveolae biogenesis. In addition, multiple studies aimed to investigate the expression and the regulation of these proteins significantly contributed to elucidate the role of caveolae and caveolins in endothelial cell physiology and disease. The aim of this review is to survey recent evidence of the involvement of the caveolar network in endothelial cell biology and endothelial cell dysfunction. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | STAMPA |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/29637636; info:eu-repo/semantics/altIdentifier/wos/WOS:000434127400005; volume:119; issue:7; firstpage:5060; lastpage:5071; numberofpages:12; journal:JOURNAL OF CELLULAR BIOCHEMISTRY; http://hdl.handle.net/11573/1323695Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85045119312 |
| DOI: | 10.1002/jcb.26793 |
| الإتاحة: | https://doi.org/10.1002/jcb.26793Test http://hdl.handle.net/11573/1323695Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.89487E74 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1002/jcb.26793 |
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