دورية أكاديمية
Tolerability of four-drug antiretroviral combination therapy in primary HIV-1 infection
| العنوان: | Tolerability of four-drug antiretroviral combination therapy in primary HIV-1 infection |
|---|---|
| المؤلفون: | Burns, JE, Stöhr, W, Kinloch-De Loes, S, Fox, J, Clarke, A, Nelson, M, Thornhill, J, Babiker, A, Frater, J, Pett, SL, Fidler, S |
| المصدر: | HIV Medicine , 22 (8) pp. 770-774. (2021) |
| سنة النشر: | 2021 |
| المجموعة: | University College London: UCL Discovery |
| مصطلحات موضوعية: | adherence, antiretroviral therapy, primary HIV-1 infection, tolerability |
| الوصف: | OBJECTIVES: Rapid initiation of antiretroviral therapy (ART) is important for individuals with high baseline viral loads, such as in primary HIV-1 infection (PHI). Four-drug regimens are sometimes considered; however, data are lacking on tolerability. We aimed to evaluate the tolerability of four-drug regimens used in the Research in Viral Eradication of HIV-1 Reservoirs (RIVER) study. METHODS: At enrolment, ART-naïve adult participants or those newly commenced on ART were initiated or intensified to four-drug regimens within 4 weeks of PHI. Rapid start was defined as pre-confirmation or ≤ 7 days of confirmed diagnosis. Primary and secondary outcomes were patient-reported adherence measured by 7-day recall and regimen switches between enrolment and randomization, respectively. RESULTS: Overall, 54 men were included: 72.2% were of white ethnicity, with a median age of 32 years old, 42.6% had a viral load of ≥ 100 000 HIV-1 RNA copies/mL, and in 92.6% sex with men was the mode of acquisition of HIV-1. Twenty (37%) started a four-drug regimen and 34 (63%) were intensified. Rapid ART initiation occurred in 28%, 100% started in ≤ 4 weeks. By weeks 4, 12, and 24, 37.0%, 69.0%, and 94.0% were undetectable (viral load < 50 copies/mL), respectively. Adherence rates of 100% at weeks 4, 12, 22 and 24 were reported in 88.9%, 87.0%, 82.4% and 94.1% of participants, respectively. Five individuals switched to three drugs, four changed their regimen constituents, and two switched post-randomization. CONCLUSIONS: Overall, four-drug regimens were well tolerated and had high levels of adherence. Whilst their benefit over three-drug regimens is lacking, our findings should provide reassurance if a temporarily intensified regimen is clinically indicated to help facilitate treatment. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | text |
| اللغة: | English |
| العلاقة: | https://discovery.ucl.ac.uk/id/eprint/10127543/16/Stohr_HIV%20Medicine%20-%202021%20-%20Burns%20-%20Tolerability%20of%20four%E2%80%90drug%20antiretroviral%20combination%20therapy%20in%20primary%20HIV%E2%80%901%20infection.pdfTest; https://discovery.ucl.ac.uk/id/eprint/10127543Test/ |
| الإتاحة: | https://discovery.ucl.ac.uk/id/eprint/10127543/16/Stohr_HIV%20Medicine%20-%202021%20-%20Burns%20-%20Tolerability%20of%20four%E2%80%90drug%20antiretroviral%20combination%20therapy%20in%20primary%20HIV%E2%80%901%20infection.pdfTest https://discovery.ucl.ac.uk/id/eprint/10127543Test/ |
| حقوق: | open |
| رقم الانضمام: | edsbas.89385982 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |