دورية أكاديمية
Direct C−H Arylation of Indole‐3‐Acetic Acid Derivatives Enabled by an Autonomous Self‐Optimizing Flow Reactor
| العنوان: | Direct C−H Arylation of Indole‐3‐Acetic Acid Derivatives Enabled by an Autonomous Self‐Optimizing Flow Reactor |
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| المؤلفون: | Vasudevan, N., Wimmer, Eric, Barré, Elvina, Cortés‐borda, Daniel, Rodriguez-Zubiri, Mireia, Felpin, Francois-Xavier |
| المساهمون: | Chimie Et Interdisciplinarité : Synthèse, Analyse, Modélisation (CEISAM), Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), Université de Nantes (UN)-Université de Nantes (UN)-Institut de Chimie - CNRS Chimie (INC-CNRS)-Centre National de la Recherche Scientifique (CNRS) |
| المصدر: | ISSN: 1615-4150. |
| بيانات النشر: | HAL CCSD Wiley-VCH Verlag |
| سنة النشر: | 2021 |
| المجموعة: | Université de Nantes: HAL-UNIV-NANTES |
| مصطلحات موضوعية: | Self-Optimizing flow reactor, Flow chemistry, Direct C-H arylation, Autonomous synthesis, Indole, [CHIM.ORGA]Chemical Sciences/Organic chemistry |
| الوصف: | International audience ; Described herein is a continuous‐flow strategy for the palladium‐catalyzed direct C−H arylation of indole‐3‐acetic acid derivatives with arenediazonium salts. A fully autonomous self‐optimizing flow platform was used to efficiently optimize the coupling reaction in a three‐dimensional space. The flow methodology developed is experimentally simple, mild, broad in scope, and safer than traditional batch approaches. Our continuous‐flow approach is particularly convenient to prepare precursors of pharmaceutically relevant compounds. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | hal-03143311; https://hal.science/hal-03143311Test; https://hal.science/hal-03143311/documentTest; https://hal.science/hal-03143311/file/AdvSynthCatal2021_Manuscript-Felpin-11112020.pdfTest |
| DOI: | 10.1002/adsc.202001217 |
| الإتاحة: | https://doi.org/10.1002/adsc.202001217Test https://hal.science/hal-03143311Test https://hal.science/hal-03143311/documentTest https://hal.science/hal-03143311/file/AdvSynthCatal2021_Manuscript-Felpin-11112020.pdfTest |
| حقوق: | info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.892FFCB |
| قاعدة البيانات: | BASE |
| DOI: | 10.1002/adsc.202001217 |
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